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Hedgehog

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Hedgehog

结构式 货号 产品名称 CAS号
Robotnikinin 结构式
BCP20109 Robotnikinin 1132653-79-2
Robotnikinin is an inhibitor of Shh signaling in a concentration-dependant manner.
Jervine 结构式
BCP28214 介芬胺 469-59-0
Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.
Saridegib hydrochloride 结构式
BCP21080 Saridegib hydrochloride 1169829-40-6
Saridegib is an orally bioavailable, cyclopamine-derived inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity.
JK184 结构式
BCP21568 JK184 315703-52-7
JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells.
TAK-441 结构式
BCP20946 TAK-441 1186231-83-3
TAK-441 is a potent inhibitor of Hedgehog (Hh) signaling pathway.
GANT61 结构式
BCP08050 GANT61 500579-04-4
GANT 61 is a small molecule inhibitor of Gli1 and Gli2.
SAG 结构式
BCP14694 SAG 912545-86-9
SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM).
MK-4101 结构式
BCP18385 MK-4101 935273-79-3
MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. MK-401 Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. MK-4101 showed anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells.
PF-5274857 结构式
BCP06737 PF-5274857 73615-35-0;1373615-35-0
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.
Erismodegib 结构式
BCP02275 索尼吉布 956697-53-3
LDE225 is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity.
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