S49076 HCl
| CAS号 | 1265966-31-1 | 货号 | BCP29576 |
| 中文名 | S49076 HCl | ||
| 英文名 | S49076 HCl | ||
| 中文别名 | |||
| 英文别名 | 1265965-19-2;S 49076 HCl;S-49076 HCl;S-49076 Hydrochloride;S49076 Hydrochloride;S 49076 Hydrochloride; | ||
| 分子式 | C22H23ClN4O4S | 分子量 | 474.96 |
| 生物活性 | S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 was established and correlated well with impact on tumor growth. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | TAM Receptor c Met FGFR | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！