Morphothiadin（GLS4）
| CAS No. | 1092970-12-1 | Cat. No. | BCP29837 |
| Name | Morphothiadin（GLS4） | ||
| Synonyms | GLS4; GLS-4; GLS 4; | ||
| Formula | C21H22BrFN4O3S | M. Wt | 509.39 |
| Description | Morphothiadin, also known GLS4, is a potent and selective inhibitor of hepatitis B virus. GLS4 demonstrated potent inhibitory activities in HBV HepG2.2.15 cell assay with an EC50 value of 1nM, and it also exhibited high potency against various drug-resistant HBV viral strains with EC50 values in the range of 10-20nM, more potent than the typical HBV polymerase inhibitors such as lamivudine, telbivudine, and entecavir. Pharmacokinetic profiles of GLS4 were favorable and safety evaluation including acute toxicity and repeated toxicity study indicated that GLS4 was safe enough to support clinical experiments in human. | ||
| Related Products | Mmethanesulfonate （Morphothiadin methanesulfonate） | ||
| Pathways | Microbiology/Virology | ||
| Targets | HBV | ||
Structure
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