Morphothiadin methanesulfonate

  • Chemical Properties
CAS No. Mmethanesulfonate Cat. No. BCP29839
Name Morphothiadin methanesulfonate
Synonyms GLS4 methanesulfonate; GLS-4 methanesulfonate; GLS 4 methanesulfonate;
Formula C22H26BrFN4O6S2 M. Wt 605.49
  • Biological Activity
Description Morphothiadin, also known GLS4, is a potent and selective inhibitor of hepatitis B virus. GLS4 demonstrated potent inhibitory activities in HBV HepG2.2.15 cell assay with an EC50 value of 1nM, and it also exhibited high potency against various drug-resistant HBV viral strains with EC50 values in the range of 10-20nM, more potent than the typical HBV polymerase inhibitors such as lamivudine, telbivudine, and entecavir. Pharmacokinetic profiles of GLS4 were favorable and safety evaluation including acute toxicity and repeated toxicity study indicated that GLS4 was safe enough to support clinical experiments in human.
Related Products 1092970-12-1(Morphothiadin)
Pathways Microbiology/Virology 
Targets HBV 

Structure

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