KYA1797K
| CAS号 | 1956356-56-1 | 货号 | BCP29963 |
| 中文名 | KYA1797K | ||
| 英文名 | KYA1797K | ||
| 中文别名 | |||
| 英文别名 | KYA1797K potassium salt; | ||
| 分子式 | C17H11N2O6S2.K | 分子量 | 442.50 |
| 生物活性 | KYA1797K is an inhibitor of both Wnt/β-catenin and Ras pathways. It binds to the axin regulators of the G-protein signaling (RGS) domain enhancing formation of the β-catenin destruction complex and inducing activation GSK3β, which results in phosphorylation and subsequent degradation of both β-catenin and K-Ras. KYA1797K was show to suppress tumor growth and progression in mouse xenografts of CRC cells that had APC and K-Ras mutations. | ||
| 信号通路 | Wnt/Stem Cell | ||
| 靶 点 | Beta catenin Wnt | ||
结构式
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