LOXO-101 HCl salt
| CAS号 | 1919868-83-9 | 货号 | BCP30585 |
| 中文名 | LOXO-101 HCl salt | ||
| 英文名 | LOXO-101 HCl salt | ||
| 中文别名 | |||
| 英文别名 | LOXO101 HCl salt；LOXO 101 HCl salt；Larotrectinib HCl;LOXO-101 Hydrochloric; | ||
| 分子式 | C21H23ClF2N6O2 | 分子量 | 464.90 |
| 生物活性 | LOXO-101 is an orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation, which results in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress Trk. Trk, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | Trk Receptor | ||
结构式
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