TH263
| CAS No. | 313520-94-4 | Cat. No. | BCP32731 |
| Name | TH263 | ||
| Synonyms | TH-263;TH 263; | ||
| Formula | C21H20N2O3S | M. Wt | 380.46 |
| Description | TH-263 is an inactive analog control for the type III allosteric LIM-kinase (LIMK) inhibitors TH-257, TH-255 and TH-251. LIM kinases belong to the family of cytoplasmic tyrosine-like kinases with dual specificity (serine/threonine and tyrosine). However, known LIMK substrate are usually phosphorylated at serine and threonine residues LIM kinases comprises LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) which show 50% sequence identity in human. Both LIMK1 and LIMK2 present with a unique domain organization containing two N-terminal LIM domains, a PDZ domain, a proline/serine-rich domain and a C-terminal kinase domain. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | LIMK | ||
Structure
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