Org 25543 hydrochloride
| CAS No. | 495076-64-7 | Cat. No. | BCP33172 |
| Name | Org 25543 hydrochloride | ||
| Synonyms | ORG25543 HCl; Org 25543 HCl;Org-25543 HCl; | ||
| Formula | C24H32lN2O4.HCl | M. Wt | 448.99 |
| Description | Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | GlyT | ||
Structure
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