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Ion Channel/Membrane Transporter

Chemical Structure Cat. No. Product Name CAS No.
Pico145 Chemical Structure
 BCP35558 Pico145 1628287-16-0
Pico145, also known as HC-608, is a potent inhibitor of TRPC1/4/5 channels.
Cyclic ADP-ribose Chemical Structure
 BCP35557 Cyclic ADP-ribose 119340-53-3
Cyclic ADP-ribose is a cyclic purine nucleotide that is synthesised from NAD+ by ADP-ribosyl cyclase; acts as an agonist at ryanodine receptors.
Procainamide Chemical Structure
 BCP35189 Procainamide 51-06-9
Procainamide is an oral antiarrhythmic agent that has been in use for more than 60 years. Long term procainamide therapy is known to induce hypersensitivity reactions, autoantibody formation and a lupus-like syndrome but is a rare cause of clinically apparent acute liver injury.
PSEM 89S TFA Chemical Structure
 BCP35173 PSEM 89S TFA 1336913-03-1
PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively.
Mizagliflozin Chemical Structure
 BCP35148 Mizagliflozin 666843-10-3
Mizagliflozin (DSP-3235, KGA-3235, GSK-1614235) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation.
Amiodarone Chemical Structure
 BCP35085 Amiodarone 1951-25-3
Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
CCMI Chemical Structure
 BCP35052 CCMI 917837-54-8
CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction.
EN6 Chemical Structure
 BCP34911 EN6 1808714-73-9
EN6 is a novel covalent autophagy activator targeting cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase which activates mTORC1 via the Rag guanosine triphosphatases.
Carboxyamidotriazole Orotate Chemical Structure
 BCP34906 Carboxyamidotriazole Orotate 187739-60-2
Carboxyamidotriazole Orotate is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate shows anti-tumor, anti-inflammatory and antiangiogenic effects.
Cav 2.2 blocker 1 Chemical Structure
 BCP34882 Cav 2.2 blocker 1 1567335-29-8
Cav 2.2 blocker 1 is a N-type calcium channel (Cav 2.2) blocker for the treatment of pain, with an IC50 of 1 nM.
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