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PI3K/Akt/mTOR

Chemical Structure Cat. No. Product Name CAS No.
BIO-acetoxime Chemical Structure
BCP27976 BIO-acetoxime 667463-85-6
BIO-acetoxime (BIA) is a potent and selective GSK-3 inhibitor, with IC50s of both 10 nM for GSK-3α/β. BIO-acetoxime has anticonvulsant and anti-infection activity.
LM22B-10 Chemical Structure
BCP30139 LM22B-10 342777-54-2
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.
PIT 1 Chemical Structure
BCP27689 PIT 1 53501-41-0
PIT-1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP3/Akt PH domain binding with an IC50 value of 31 μM.
MK-2206 Chemical Structure
BCP20200 MK-2206 1032349-93-1
MK-2206 is a highly selective inhibitor of pan-Akt, namely, of all three Akt isoforms Akt1, Akt2, and Akt3.
GDC-0077 Chemical Structure
BCP25972 GDC-0077 2060571-02-8
GDC-0077 is a potent and selective PI3K inhibitor. GDC-0077 blocks an enzyme involved in cancer growth called PI3K.
SAR-260301 Chemical Structure
BCP13808 SAR-260301 1260612-13-2
SAR260301 is potent and selective Class I phosphatidylinositol-3-kinase (PI3K)β specific inhibitor with an IC50 of 52 nM for this isoform.
Akt-I-2 HCl Chemical Structure
BCP18315 Akt-I-2 HCl 473382-50-2
Akt-I-1,2 is a selective Akt1 and Akt2 inhibitor.
BAY-1125976 Chemical Structure
BCP20659 BAY-1125976 1402608-02-9
BAY1125976 is a selective allosteric Akt1/2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
ATR inhibitor 1 Chemical Structure
BCP23596 ATR inhibitor 1 1613200-51-3
Carnosol Chemical Structure
BCP20030 Carnosol 5957-80-2
Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM.
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