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PI3K/Akt/mTOR

Chemical Structure Cat. No. Product Name CAS No.
Nemiralisib Chemical Structure
BCP38658 Nemiralisib 1254036-71-9
Nemiralisib, also known as GSK2269557, is a highly potent and selective inhaled PI3Kδ inhibitor for the treatment of COPD.
KY19382 Chemical Structure
BCP38332 KY19382 2226664-93-1
KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively.
AZD6738 chiral mixtures Chemical Structure
BCP38320 AZD6738 chiral mixtures 1352280-97-7
AZD6738 is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.
(S)-Ceralasertib Chemical Structure
BCP38319 (S)-Ceralasertib 1352226-87-9
(S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics.
MT 63-78 Chemical Structure
BCP38015 MT 63-78 1179347-65-9
MT 63-78 is a direct activator of AMPK, and an inhibitor of prostate cancer growth by blocking lipogenesis.
SAR405 R enantiomer Chemical Structure
BCP37991 SAR405 R enantiomer 1946010-79-2
SAR405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells.
PS210 Chemical Structure
BCP37870 PS210 1221962-86-2
PS210 is a substrate-selective inhibitor of protein kinase PDK1.
CGS 15943 Chemical Structure
BCP37843 CGS 15943 104615-18-1
CGS 15943 is a potent adenosine receptor antagonist (Ki values are 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively).
6-Nitroveratraldehyde Chemical Structure
BCP37748 6-Nitroveratraldehyde 20357-25-9
6-Nitroveratraldehyde is a derivative of vanillin with 100-fold potency compared to vanillin, and acts as an inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 15 μM).
AZ32 Chemical Structure
BCP37674 AZ32 2288709-96-4
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
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