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PI3K/Akt/mTOR

Chemical Structure Cat. No. Product Name CAS No.
Leniolisib Chemical Structure
BCP30455 Leniolisib 1354690-24-6
Leniolisib, also known CDZ173, is a potent phosphatidylinositol 3-kinase inhibitor (PI3K inhibitor).
PWT143 Chemical Structure
BCP30431 PWT143 1595129-71-7
PWT143, also known as ME-401, is an orally bioavailable inhibitor of the delta isoform of phosphatidylinositide 3-kinase (PI3K), with potential antineoplastic activity.
MK-8722 Chemical Structure
BCP30296 MK-8722 1394371-71-1
MK8722 is a potent and systemic pan-AMPK activator
Fluorofenidone Chemical Structure
BCP10850 Fluorofenidone 848353-85-5
Fluorofenidone is an inhibitor of nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis.
KU 60019 Chemical Structure
BCP30241 KU 60019 925701-46-8
KU-60019 is an improved ATM kinase-specific inhibitor with IC50 of 6.3 nM.
BIO-acetoxime Chemical Structure
BCP27976 BIO-acetoxime 667463-85-6
BIO-acetoxime (BIA) is a potent and selective GSK-3 inhibitor, with IC50s of both 10 nM for GSK-3α/β. BIO-acetoxime has anticonvulsant and anti-infection activity.
LM22B-10 Chemical Structure
BCP30139 LM22B-10 342777-54-2
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.
PIT 1 Chemical Structure
BCP27689 PIT 1 53501-41-0
PIT-1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP3/Akt PH domain binding with an IC50 value of 31 μM.
MK-2206 Chemical Structure
BCP20200 MK-2206 1032349-93-1
MK-2206 is a highly selective inhibitor of pan-Akt, namely, of all three Akt isoforms Akt1, Akt2, and Akt3.
GDC-0077 Chemical Structure
BCP25972 GDC-0077 2060571-02-8
GDC-0077 is a potent and selective PI3K inhibitor. GDC-0077 blocks an enzyme involved in cancer growth called PI3K.
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