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PI3K/Akt/mTOR

Chemical Structure Cat. No. Product Name CAS No.
Recilisib sodium Chemical Structure
BCP35048 Recilisib sodium 922139-31-9
Recilisib is a radioprotectant, which can activate AKT, PI3K activities in cells.
E-Guggulsterone Chemical Structure
BCP34834 E-Guggulsterone 39025-24-6
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii.
(Z)-Guggulsterone Chemical Structure
BCP07472 (Z)-Guggulsterone 39025-23-5
Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.
Alpelisib hydrochloride Chemical Structure
BCP34729 Alpelisib hydrochloride 1584128-91-5
Alpelisib hydrochloride is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM, 250 nM, 290 nM and 1200 nM for p110α, p110γ, p110δ, and p110β, respectively.
PI4KA inhibitor-F1 Chemical Structure
BCP34465 PI4KA inhibitor-F1 1384097-27-1
PI4KA inhibitor-F1 is a potent inhibitor of PI4KA.
Parsaclisib Chemical Structure
BCP33523 Parsaclisib 1426698-88-5
Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
MDK34597 Chemical Structure
BCP25529 MDK34597 371934-59-7
MDK34597 is a PI3K inhibitor.
Rapalink-1 Chemical Structure
BCP33282 Rapalink-1 Rapalink-1
RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin with MLN0128 (a second-generation mTOR kinase inhibitor) by an inert chemical linker.
Alsterpaullone Chemical Structure
BCP33241 Alsterpaullone 237430-03-4
Alsterpaullone, also known as 9-Nitropaullone and NSC 705701, is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β).
Umbralisib hydrochloride Chemical Structure
BCP24682 Umbralisib hydrochloride 1532533-78-0
Umbralisib hydrochloride is the hydrochloride salt of TGR-1202.TGR-1202 HCl is a potent PI3Kδ inhibitor.
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