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PI3K/Akt/mTOR

Chemical Structure Cat. No. Product Name CAS No.
Parsaclisib Chemical Structure
BCP33523 Parsaclisib 1426698-88-5
Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
MDK34597 Chemical Structure
BCP25529 MDK34597 371934-59-7
MDK34597 is a PI3K inhibitor.
Rapalink-1 Chemical Structure
BCP33282 Rapalink-1 Rapalink-1
RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin with MLN0128 (a second-generation mTOR kinase inhibitor) by an inert chemical linker.
Alsterpaullone Chemical Structure
BCP33241 Alsterpaullone 237430-03-4
Alsterpaullone, also known as 9-Nitropaullone and NSC 705701, is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β).
Umbralisib hydrochloride Chemical Structure
BCP24682 Umbralisib hydrochloride 1532533-78-0
Umbralisib hydrochloride is the hydrochloride salt of TGR-1202.TGR-1202 HCl is a potent PI3Kδ inhibitor.
AZD8055 Fumaric acid Chemical Structure
BCP25958 AZD8055 Fumaric acid 1201799-05-4
AZD-8055 is a novel ATP-competitive inhibitor of mTOR kinase with an IC50 of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2.
AZD8055 D(-)-Tartaric Acid Chemical Structure
BCP25959 AZD8055 D(-)-Tartaric Acid 1201799-04-3
AZD-8055 is a novel ATP-competitive inhibitor of mTOR kinase with an IC50 of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2.
CHIR-99021 trihydrochloride Chemical Structure
BCP26069 CHIR-99021 trihydrochloride 1782235-14-6
CHIR99021 is an orally active and potent GSK3 inhibitor. CHIR-73911 exhibited GSK3 IC50 in the low nanomolar range and excellent selectivity. CHIR-73911 activates glycogen synthase in insulin receptorexpressing CHO-IR cells and primary rat hepatocyte
mTOR inhibitor-1 Chemical Structure
BCP32690 mTOR inhibitor-1 468747-17-3
mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy.
XL-765 Chemical Structure
BCP32612 XL-765 1123889-87-1
XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.
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