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PI3K/Akt/mTOR

Chemical Structure Cat. No. Product Name CAS No.
XL-765 Chemical Structure
BCP32612 XL-765 1123889-87-1
XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.
PF-06409577 Chemical Structure
BCP32554 PF-06409577 1467057-23-3
PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.
Vps34-IN-2 Chemical Structure
BCP26194 Vps34-IN-2 1523404-29-6
Vps34-IN-2 is a novel, potent and selective inhibitor of Vps34 with IC50s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively.
GSK621 Chemical Structure
BCP31970 GSK621 1346607-05-3
GSK621 is a specific and potent AMPK activator.
MOTS-c (human) Chemical Structure
BCP31969 MOTS-c (human) 1627580-64-6
MOTS-c is a Mitochondria-derived peptide (MDP). Promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK).
BAY-1895344 hydrochloride Chemical Structure
BCP31861 BAY-1895344 hydrochloride BAY-1895344HCl
BAY-1895344 hydrochloride is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity.
Miransertib HCl Chemical Structure
BCP25709 Miransertib HCl 1313883-00-9
Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.
GNF4877 Chemical Structure
BCP31624 GNF4877 2041073-22-5
GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM.
Ipatasertib dihydrochloride Chemical Structure
BCP23821 Ipatasertib dihydrochloride 1396257-94-5
Ipatasertib dihydrochloride is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA.
Recilisib Chemical Structure
BCP31296 Recilisib 334969-03-8
Recilisib is a radioprotectant, which can activate AKT, PI3K activities in cells.
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