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Chemical Structure Cat. No. Product Name CAS No.
Pim1/AKK1-IN-1 Chemical Structure
BCP27625 Pim1/AKK1-IN-1 1093222-27-5
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
LGB321 Chemical Structure
BCP13641 LGB321 1210415-88-5
LGB-321 is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor).
TP-3654 Chemical Structure
BCP30070 TP-3654 1361951-15-6
TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively.
LGH447 Hydrochloride Chemical Structure
BCP24206 LGH447 Hydrochloride 1210416-52-6
LGH447 Hydrochloride is Potent and specific pan-PIM inhibitor, inhibiting proliferation of several AML cell lines, showing dual antitumoral and bone antiresorptive effects.
M-110 Chemical Structure
BCP25255 M-110 1395048-49-3
M-110 is a novel and highly selective inhibitor of PIM kinases; inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 uM, with no activity on normal human peripheral blood mononuclear cells up to 40 uM.
SMI-16a Chemical Structure
BCP20644 SMI-16a 587852-28-6
Novel potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively)
PIM447 Chemical Structure
BCP19936 PIM447 1210608-43-7
PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase.
AZD-1208 Chemical Structure
BCP08968 AZD-1208 1204144-28-4
AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.
CX 6258 hydrochloride hydrate Chemical Structure
BCP19056 CX 6258 hydrochloride hydrate 1353858-99-7
CX-6258 hydrochloride hydrate is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity.
SMI-4a Chemical Structure
BCP06044 SMI-4a 438190-29-5; 327033-36-3
Selective, ATP-competitive Pim kinase inhibitor (IC50 values are 24 and 100 nM for Pim-1 and Pim-2 respectively). Displays selectivity over a panel of ~50 other kinases tested. Exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro (IC50 = 17 μM).
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