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CXCR

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CXCR

Chemical Structure Cat. No. Product Name CAS No.
NSC-23026 Chemical Structure
BCP29974 NSC-23026 6616-56-4
NSC-23026, also known as MSX-127, is a CXCR4 receptor modulator.
LIT-927 Chemical Structure
BCP29866 LIT-927 2172879-52-4
LIT-927 (LIT927) is the first selective, locally and orally active CXCL12 neutraligand with Ki of 267 nM for CXCL12-TR binding inhibition; displays excellent selectivity over other chemokines (CCL17, CCL22, CCL5 and CCL2).
SB-265610 Chemical Structure
BCP28242 SB-265610 211096-49-0
SB-265610 is a potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca2+ mobilization (IC50 values are 3.4 and 6800 nM respectively).
AMG-487 Chemical Structure
BCP23713 AMG-487 473719-41-4
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) with IC50 values of 8nM and 8.2nM for I-IP-10 and I-ITAC, respectively.
UNBS-5162 Chemical Structure
BCP23948 UNBS-5162 956590-23-1
UNBS5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers; the mean antiproliferative activity IC50 value is 17.9 uM for 9 cancer cell lines; hydrolysis product of UNBS3157.
ZK-811752 Chemical Structure
BCP10157 ZK-811752 217645-70-0
BX471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1); exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
AMD 3465 hexahydrobromide Chemical Structure
BCP06454 AMD 3465 hexahydrobromide 185991-07-5
Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100.
AMD-070 Chemical Structure
BCP07108 AMD-070 558447-26-0
AMD-070 is an orally bioavailable and potent CXCR4 inhibitor.
AZD5069 Chemical Structure
BCP23519 AZD5069 878385-84-3
AZD-5069 is a potent CXCR2 chemokine receptor antagonist, used for caner treatment.
SRT3109 Chemical Structure
BCP02519 SRT3109 1204707-71-0
SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions.
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