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p53

Chemical Structure Cat. No. Product Name CAS No.
Pifithrin-β hydrobromide Chemical Structure
BCP17578 Pifithrin-β hydrobromide 511296-88-1
Pifithrin-β is a potent p53 inhibitor with an IC50 of 23 μM.
CP 31398 Chemical Structure
BCP14611 CP 31398 259199-65-0
CP 31398 dihydrochloride is a potent activator of p53 with maximum tolerated dose of 400 ppm.
CBL0137 Chemical Structure
BCP29977 CBL0137 1197996-80-7
CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 μM and inhibits NF-κB with an EC50 of 0.47 μM.
Prima-1 Chemical Structure
BCP26191 Prima-1 5608-24-2
Prima-1 is an inhibitor of the growth of cell lines derived from various human tumor types in a mutant p53-dependent manner.
COTI-2 Chemical Structure
BCP28961 COTI-2 1039455-84-9
COTI-2 is a small molecule candidate anti-cancer drug which can convert mutant p53 to wild-type conformation.
NSC319726 Chemical Structure
BCP28106 NSC319726 71555-25-4
NSC319726 is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM); shows no inhibition for p53 wild-type cells.
Kevetrin Chemical Structure
BCP28785 Kevetrin 500863-50-3
Kevetrin ( thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
FL118 Chemical Structure
BCP12571 FL118 151636-76-9
FL118 is an inhibitor of human survivin expression, activating tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells.
HDM201 Chemical Structure
BCP20814 HDM201 1448867-41-1
HDM201 is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity.
VLX600 Chemical Structure
BCP10627 VLX600 1622945-04-3
VLX600 induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs. VLX600 is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.
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