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Chemical Structure Cat. No. Product Name CAS No.
RBN012759 Chemical Structure
BCP42877 RBN012759 2360851-29-0
RBN012759 is a potent and selective inhibitor of PARP14 with IC50 of <3 nM and 5 nM for human catalytic domain and mouse catalytic domain, respectively. RBN012759 contributes to anti-tumor immune response.
BD750 Chemical Structure
BCP42671 BD750 892686-59-8
BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.
BC1618 Chemical Structure
BCP42670 BC1618 2222094-18-8
BC1618 is a novel Fbxo48 inhibitor and prevent pAmpkα degradation with MEC (minimal efficacious concentration) of 0.6 μM.
SB1317 Chemical Structure
BCP42651 SB1317 1204918-72-8
SB1317 is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. Zotiraciclib may be useful for the treatment of cancer that crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9). It is one of a number of CDK inhibitors under investigation; others targeting CDK9 for the treatment of acute myeloid leukemia include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, with 80 percent of glioblastomas characterized by this property.
SIRT-IN-2 Chemical Structure
BCP41849 SIRT-IN-2 1431411-66-3
SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively.
BAY-299 Chemical Structure
BCP41584 BAY-299 2080306-23-4
BAY-299 is a potent and selective BRD1 and TAF1 inhibitor (IC50 values are 6 and 13 nM, respectively).
UMB298 Chemical Structure
BCP41242 UMB298 2266569-73-5
UMB298 is a Potent and Selective CBP/P300 Inhibitor with CBP IC50= 72 nM.
DR2313 Chemical Structure
BCP40859 DR2313 284028-90-6
DR 2313 has been found to be a PARP-1/PARP-2 inhibitor and could exhibit neuroprotective avtivities as well as reduce cortical infarct volume in focal ischemia.
SHR0302 Chemical Structure
BCP34833 SHR0302 1445987-21-2
SHR0302 is a novel potent JAK inhibitor, blocking JAK/STAT3 signaling, suppressing proliferation, migration and collagen production, and inducing the apoptosis of hepatic stellate cells.
MRK-740 Chemical Structure
BCP40609 MRK-740 2387510-80-5
MRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor.
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