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Angiogenesis/Protein Tyrosine Kinase
c Met

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c Met

Chemical Structure Cat. No. Product Name CAS No.
Glumetinib Chemical Structure
BCP31155 Glumetinib 1642581-63-2
Glumetinib is a potent and highly selective c-Met kinase inhibitor with an IC50 of 0.42 nM. Glumetinib shows antitumor activity and a superior safety margin.
AMG51 Chemical Structure
BCP21618 AMG51 890019-63-3
AMG-51 is a selective inhibitor of c-Met kinase
S49076 HCl Chemical Structure
BCP29576 S49076 HCl 1265966-31-1
S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo.
SAR125844 Chemical Structure
BCP28183 SAR125844 1116743-46-4
SAR125844 is a potent and highly selective c-Met inhibitor with potential antineoplastic activity.
BMS817378 Chemical Structure
BCP15910 BMS817378 1174161-69-3
BMS-817378 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50: 1.7 nM/15 nM for Met/VEGFR2.
Ensartinib  dihydrochloride Chemical Structure
BCP29059 Ensartinib dihydrochloride 2137030-98-7
Ensartinib, also known as X-396, is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively.
Sitravatinib Chemical Structure
BCP29099 Sitravatinib 1123837-84-2
Sitravatinib (MGCD516,MG-516) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl.
Ensartinib Chemical Structure
BCP26265 Ensartinib 1370651-20-9
Ensartinib, also known as X-396, is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity.
AMG-208 Chemical Structure
BCP01384 AMG-208 1002304-34-8
AMG-208 (AMG 208, AMG208) is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.
MK2461 Chemical Structure
BCP09219 MK2461 917879-39-1
MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met with a mean IC50 of 2.5 nM.
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