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Wnt

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Wnt

Chemical Structure Cat. No. Product Name CAS No.
PRI-724 Chemical Structure
BCP32677 PRI-724 1422253-38-0
PRI-724 is a selective inhibitor of the CBP/β-catenin interaction.
KY1220 Chemical Structure
BCP34008 KY1220 292168-79-7
KY1220 is a small molecule that simultaneously degrades β-catenin and Ras by inhibition of the Wnt/β-catenin pathway.
CHIR-99021 trihydrochloride Chemical Structure
BCP26069 CHIR-99021 trihydrochloride 1782235-14-6
CHIR99021 is an orally active and potent GSK3 inhibitor. CHIR-73911 exhibited GSK3 IC50 in the low nanomolar range and excellent selectivity. CHIR-73911 activates glycogen synthase in insulin receptorexpressing CHO-IR cells and primary rat hepatocyte
iCRT3 Chemical Structure
BCP32691 iCRT3 901751-47-1
iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription.
QS11 Chemical Structure
BCP02472 QS11 944328-88-5
Additionally, Wnt Synergist, QS11 has been shown to work synergistically with Wnt-3a to specifically activate the Wnt/β-catenin signaling pathway in vitro. A Super(8X)TOPFlash reporter assay using HEK293 cells revealed increases in basal transcription activity by application of QS11 (2-fold), Wnt-3a (40-fold), and QS11/Wnt-3a (200-fold).
Adavivint Chemical Structure
BCP30409 Adavivint 1467093-03-3
Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.
KYA1797K Chemical Structure
BCP29963 KYA1797K 1956356-56-1
KYA1797K is a potent and selective Wnt/β-catenin inhibitor with an IC50 of 0.75 µM.
Gigantol Chemical Structure
BCP29252 Gigantol 67884-30-4
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells.
MN 64 Chemical Structure
BCP16851 MN 64 92831-11-3
MN-64 is a inhibitor of tankyrases, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
Triptonide Chemical Structure
BCP26007 Triptonide 38647-11-9
Triptonide(NSC 165677; PG 492), extracted from Tripterygium wilfordii Hook.
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