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P glycoprotein

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P glycoprotein

Chemical Structure Cat. No. Product Name CAS No.
Genz-123346 Chemical Structure
BCP11811 Genz-123346 491833-30-8
Genz-123346 is a potent and selective glucosylceramide synthase inhibitor with potential anticancer activity.
Cabazitaxel Chemical Structure
BCP27641 Cabazitaxel 183133-96-2
A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.
BAL27862 Chemical Structure
BCP16476 BAL27862 798577-91-0
BAL27862 is a a novel synthetic potent inhibitor of tubulin polymerization that induces cancer cell death. BAL27862 is a novel microtubule-destabilizing drug that is currently undergoing phase I clinical evaluation as the prodrug BAL101553. BAL27862 elicits a unique microtubule (MT) phenotype, distinct from paclitaxel, vinblastine and colchicine, has broad in vitro anti-proliferative activity against a diverse range of human tumor lines (low nM IC50s) and induces significant antitumor responses in a range
Piperine Chemical Structure
BCP18901 Piperine 94-62-2
Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC50 value of 61.94±0.054 μg/mL in HeLa cell.
Tariquidar methanesulfonate, hydrate Chemical Structure
BCP18814 Tariquidar methanesulfonate, hydrate 625375-83-9
Tariquidar methanesulfonate, hydrate is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1±0.9 nM).
LY335979 Chemical Structure
BCP27664 LY335979 167354-41-8
Zosuquidar (LY335979) is a potent negative modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM.
Elacridar Chemical Structure
BCP05709 Elacridar 143664-11-3
Elacridar is a P-glycoprotein and breast cancer resistance protein inhibitor that has been used to improve the brain distribution of drugs that are substrates of P-gp and BCRP.
Elacridar HCl Chemical Structure
BCP14056 Elacridar HCl 143851-98-3
Elacridar Hcl (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.
Barnidipine hydrochloride Chemical Structure
BCP12810 Barnidipine hydrochloride 104757-53-1
Barnidipine is a longacting calcium-channel blocker and potent inhibitor of P-glycoprotein in vitro
Zosuquidar 3HCl Chemical Structure
BCP02954 Zosuquidar 3HCl 167465-36-3
LY335979 (Zosuquidar) is a selective Pgp (P-glycoprotein) inhibitor with a Ki of 59 nM.
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