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p38 MAPK

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p38 MAPK

Chemical Structure Cat. No. Product Name CAS No.
AZD7624 Chemical Structure
 BCP37429 AZD7624 1095004-78-6
AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.
MW-150 Chemical Structure
 BCP34874 MW-150 1628502-91-9
MW-150 is a novel potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM
SB 203580 hydrochloride Chemical Structure
 BCP29070 SB 203580 hydrochloride 869185-85-3
SB 203580 hydrochloride is a widely used p38 MAPK inhibitor. SB 203580 hydrochloride (RWJ 64809 hydrochloride) inhibits SAPK2a/p38 and SAPK2b/p38β2, with IC50s of 50 nM and 500 nM, respectively. LCK, GSK3β and PKBα are also inhibited by SB 203580 hydrochloride, but the IC50s are 100-500-fold higher than that for SAPK2a/p38.
LY2322600 Chemical Structure
 BCP27665 LY2322600 862505-01-9
LY2228820 is a novel and potent p38MAPK inhibitor.
MW-150 dihydrochloride dihydrate Chemical Structure
 BCP30837 MW-150 dihydrochloride dihydrate 1661020-92-3
MW-150 dihydrochloride dihydrate is a selective inhibitor of p38αMAPK isoform with a Ki of 101 nM.
ITX-5061 HCl Chemical Structure
 BCP30784 ITX-5061 HCl 1252679-52-9
ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).
Pexmetinib Chemical Structure
 BCP28410 Pexmetinib 945614-12-0
Pexmetinib is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia.
SD-06 Chemical Structure
 BCP21625 SD-06 271576-80-8
SD-06 is a MAPK p38 alpha inhibitor for the treatment of arthritis.
SB202190 HCl Chemical Structure
 BCP21617 SB202190 HCl 350228-36-3
SB 202190 inhibits p38 and p38β2 with IC50 values of 50 nM and 100 nM. respectively.
R1487 Chemical Structure
 BCP29574 R1487 449811-92-1
R1487 is a p38 MAP kinase inhibitor with an IC50 of 10nM.
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