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p38 MAPK

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p38 MAPK

Chemical Structure Cat. No. Product Name CAS No.
SB 203580 hydrochloride Chemical Structure
 BCP29070 SB 203580 hydrochloride 869185-85-3
SB 203580 hydrochloride is a widely used p38 MAPK inhibitor. SB 203580 hydrochloride (RWJ 64809 hydrochloride) inhibits SAPK2a/p38 and SAPK2b/p38β2, with IC50s of 50 nM and 500 nM, respectively. LCK, GSK3β and PKBα are also inhibited by SB 203580 hydrochloride, but the IC50s are 100-500-fold higher than that for SAPK2a/p38.
LY2322600 Chemical Structure
 BCP27665 LY2322600 862505-01-9
LY2228820 is a novel and potent p38MAPK inhibitor.
MW-150 dihydrochloride dihydrate Chemical Structure
 BCP30837 MW-150 dihydrochloride dihydrate 1661020-92-3
MW-150 dihydrochloride dihydrate is a selective inhibitor of p38αMAPK isoform with a Ki of 101 nM.
ITX-5061 HCl Chemical Structure
 BCP30784 ITX-5061 HCl 1252679-52-9
ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).
Pexmetinib Chemical Structure
 BCP28410 Pexmetinib 945614-12-0
Pexmetinib is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia.
SD-06 Chemical Structure
 BCP21625 SD-06 271576-80-8
SD-06 is a MAPK p38 alpha inhibitor for the treatment of arthritis.
SB202190 HCl Chemical Structure
 BCP21617 SB202190 HCl 350228-36-3
SB 202190 inhibits p38 and p38β2 with IC50 values of 50 nM and 100 nM. respectively.
R1487 Chemical Structure
 BCP29574 R1487 449811-92-1
R1487 is a p38 MAP kinase inhibitor with an IC50 of 10nM.
UM164 Chemical Structure
 BCP29207 UM164 903564-48-7
UM164 is a movel potent, dual c-Src/p38 with Kd of 2.7 nM (c-Src), potently inhibits both p38α and p38β; inhibits c-Src autophosphorylation in TNBC cell lines.
VX 702 Chemical Structure
 BCP28564 VX 702 745833-23-2
VX-702, one of a series of second-generation, is an orally active p38 MAP kinase inhibitors, for the potential treatment of inflammation, rheumatoid arthritis and cardiovascular diseases.
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