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GPCR/G Protein

Chemical Structure Cat. No. Product Name CAS No.
N-Methyldopamine hydrochloride Chemical Structure
BCP35497 N-Methyldopamine hydrochloride 62-32-8
N-Methyldopamine hydrochloride is an andregenic and dopamine receptor agonist; active metabolite of Ibopramine.
Siponimod fumarate Chemical Structure
BCP25217 Siponimod fumarate 1234627-85-0
Siponimod is a a potent and orally selective S1P Receptor Modulator with EC50 value of 0.39nM for S1P1 receptors and 0.98nM for S1P5 receptors, respectively.
Macimorelin Chemical Structure
BCP35453 Macimorelin 381231-18-1
Macimorelin is an orally available synthetic mimetic of the growth hormone (GH) secretagogue ghrelin with potential anti-cachexia activity.
Nebivolol Chemical Structure
BCP35441 Nebivolol 99200-09-6
Nebivolol is a beta-blocker and antihypertensive medication that has additional vasodilatory activity mediated by nitric oxide release. Nebivolol has yet to be linked to instances of clinically apparent liver injury.
ML417 Chemical Structure
BCP35340 ML417 1386162-69-1
ML417 is a selective and brain penetrant D3 dopamine receptor (D3R) agonist, with an EC50 of 38 nM. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons.
p-MPPI monohydrochloride Chemical Structure
BCP35226 p-MPPI monohydrochloride 220643-77-6
p-MPPI monohydrochloride is a selective 5-HT1A serotonin receptor antagonist, crossing the blood-brain barrier.
Metipranolol Chemical Structure
BCP35224 Metipranolol 22664-55-7
Metipranolol is a non-selective beta blocker used in eye drops to treat glaucoma. It is rapidly metabolized into desacetylmetipranolol.
PKA Inhibitor (5-24) Chemical Structure
BCP35218 PKA Inhibitor (5-24) 99534-03-9
PKA Inhibitor (5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor.
KGA-2727 Chemical Structure
BCP35207 KGA-2727 666842-36-0
KGA-2727 is a first selective, high-affinity and orally active SGLT1 inhibitor with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 has antidiabetic efficacy.
Mizagliflozin Chemical Structure
BCP35148 Mizagliflozin 666843-10-3
Mizagliflozin (DSP-3235, KGA-3235, GSK-1614235) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation.
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