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Trk Receptor

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Trk Receptor

Chemical Structure Cat. No. Product Name CAS No.
LOXO-101 HCl salt Chemical Structure
BCP30585 LOXO-101 HCl salt 1919868-83-9
LOXO-101 is an orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity.
LOXO195 R racemic Chemical Structure
BCP30220 LOXO195 R racemic 1350884-56-8
(6RS)-LOXO-195 is a potent and selective Trk tyrosine kinase inhibitor.The R racemate of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.
LOXO195 RS-isomer Chemical Structure
BCP30219 LOXO195 RS-isomer 2097002-59-8
The RS-isomer of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.
LM22B-10 Chemical Structure
BCP30139 LM22B-10 342777-54-2
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.
PD90780 Chemical Structure
BCP16228 PD90780 77422-99-2
PD90780 is a nonpeptide inhibitor of NGF binding to p75NTR (IC50 ~ 1 μM in CHO cells); binds NGF, not p75NTR.
AZ-23 Chemical Structure
BCP01916 AZ-23 915720-21-7
AZ-23 is a potent and selective tyrosine kinase (Trk) inhibitor having potential for therapeutic utility in neuroblastoma and multiple other cancers.
PF-06273340 Chemical Structure
BCP29619 PF-06273340 1402438-74-7
PF-06273340 is a potent, selective, and peripherally restricted Pan-Trk Inhibitor with an excellent LipE profile (IC50 value: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM).
Belizatinib Chemical Structure
BCP29521 Belizatinib 1357920-84-3
Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.
ARRY470 Chemical Structure
BCP16262 ARRY470 1223403-58-4
Larotrectinib, also known as ARRY-470 and LOXO-101, is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC.
Tavilermide Chemical Structure
BCP24696 Tavilermide 263251-78-1
Tavilermide is a nerve growth factor mimetic.
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