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Angiogenesis/Protein Tyrosine Kinase

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Chemical Structure Cat. No. Product Name CAS No.
Bevacizumab Chemical Structure
BCP07998 Bevacizumab 216974-75-3
Bevacizumab is a recombinant humanized monoclonal antibody that blocks angiogenesis by inhibiting vascular endothelial growth factor A (VEGF-A).
AAL-993 Chemical Structure
BCP18097 AAL-993 269390-77-4
AAL-993 is a highly potent inhibitor of VEGFR-1 (IC50 =130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM).
ODM-203 Chemical Structure
BCP30030 ODM-203 1430723-35-5
ODM-203 is an orally available inhibitor of the human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs), with potential antiangiogenic and antineoplastic activities.
AST-487 Chemical Structure
BCP21589 AST-487 630124-46-8
AST 487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM.
SU-5408 Chemical Structure
BCP29247 SU-5408 15966-93-5
SU5408 is a potent and cell-permeable inhibitor of VEGFR2 kinase with an IC50 of 70 nM.
Oglufanide Chemical Structure
BCP13098 Oglufanide 38101-59-6
Oglufanide inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis.
2-D08 Chemical Structure
BCP18314 2-D08 144707-18-6
2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation.
Ectoine Chemical Structure
BCP14520 Ectoine 96702-03-3
Ectoine is an inhibitor of protein misfolding. It acts by significantly down-regulating Syp, Mapk3 and Tnfα and up-regulating Vegf in rat's hippocampus, prohibiting insulin amyloid formation in vitro.
N-Desethyl Sunitinib Chemical Structure
BCP20914 N-Desethyl Sunitinib 356068-97-8
N-Desethyl Sunitinib is a metabolite of sunitinib.
BMS817378 Chemical Structure
BCP15910 BMS817378 1174161-69-3
BMS-817378 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50: 1.7 nM/15 nM for Met/VEGFR2.
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