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VEGFR

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VEGFR

Chemical Structure Cat. No. Product Name CAS No.
SU 5205 Chemical Structure
 BCP25520 SU 5205 3476-86-6
SU 5205 is a VEGFR2 inhibitor.
Vandetanib trifluoroacetate Chemical Structure
 BCP33121 Vandetanib trifluoroacetate 338992-53-3
Vandetanib trifluoroacetate is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
PTC299 Chemical Structure
 BCP32869 PTC299 1256565-36-2
PTC299 is a potent, orally bioavailable VEGFA inhibitor, targets dihydroorotate dehydrogenase (DHODH), resulting in cell growth inhibition and differentiation in leukemias, including acute myeloid leukemia, linking DHODH regulation and stress-induced VEGFA and angiogenesis.
hVEGF-IN-1 Chemical Structure
 BCP32794 hVEGF-IN-1 1637443-98-1
hVEGF-IN-1 represses human VEGF-A translation and shows antitumor activity.
JK-P3 Chemical Structure
 BCP32785 JK-P3 942655-44-9
JK-P3 is a VEGFR2 inhibitor with IC50 values of 7.8 μM.
AG1406 Chemical Structure
 BCP32621 AG1406 71308-34-4
AG1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 .
Ramucirumab Chemical Structure
 BCP26258 Ramucirumab 947687-13-0
Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D.
MAZ51 Chemical Structure
 BCP31595 MAZ51 163655-37-6
MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 μM) without blocking VEGFC-mediated stimulation of VEGFR2.
JNJ-38158471 Chemical Structure
 BCP21621 JNJ-38158471 951151-97-6
JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50=40nM.
TG 100572 Hydrochloride Chemical Structure
 BCP21364 TG 100572 Hydrochloride 867331-64-4
TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
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