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VEGFR

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VEGFR

Chemical Structure Cat. No. Product Name CAS No.
AG1406 Chemical Structure
BCP32621 AG1406 71308-34-4
AG1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 .
Ramucirumab Chemical Structure
BCP26258 Ramucirumab 947687-13-0
Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D.
MAZ51 Chemical Structure
BCP31595 MAZ51 163655-37-6
MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 μM) without blocking VEGFC-mediated stimulation of VEGFR2.
JNJ-38158471 Chemical Structure
BCP21621 JNJ-38158471 951151-97-6
JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50=40nM.
TG 100572 Hydrochloride Chemical Structure
BCP21364 TG 100572 Hydrochloride 867331-64-4
TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
Lucitanib hydrochloride Chemical Structure
BCP21230 Lucitanib hydrochloride 1058137-84-0
Lucitanib is a novel dual inhibitor of VEGFR and FGFR, potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 with IC50s of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively.
CP-547632 Chemical Structure
BCP22974 CP-547632 252003-65-9
CP-547632 is a potent inhibitor of the VEGFR2 and FGF2 kinases with IC50s of 11 and 9 nM, respectively.
Aflibercept Chemical Structure
BCP27879 Aflibercept 862111-32-8
Aflibercept is a recombinant fusion protein and acts as a VEGF inhibitor. Aflibercept is used for the treatment of wet macular degeneration and metastatic colorectal cancer.
SU5208 Chemical Structure
BCP29246 SU5208 62540-08-3
Tesevatinib Chemical Structure
BCP23438 Tesevatinib 781613-23-8
XL-647 (Tesevatinib, EXEL-7647, KD-019) is a novel spectrum-selective kinase inhibitor that potently inhibits the EGFR, ErbB2, KDR and EphB4 with IC50 of 0.3, 16, 1.5 and 1.4 nM, respectively.
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