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VEGFR

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VEGFR

Chemical Structure Cat. No. Product Name CAS No.
Aflibercept Chemical Structure
 BCP27879 Aflibercept 862111-32-8
Aflibercept is a recombinant fusion protein and acts as a VEGF inhibitor. Aflibercept is used for the treatment of wet macular degeneration and metastatic colorectal cancer.
SU5208 Chemical Structure
 BCP29246 SU5208 62540-08-3
Tesevatinib Chemical Structure
 BCP23438 Tesevatinib 781613-23-8
XL-647 (Tesevatinib, EXEL-7647, KD-019) is a novel spectrum-selective kinase inhibitor that potently inhibits the EGFR, ErbB2, KDR and EphB4 with IC50 of 0.3, 16, 1.5 and 1.4 nM, respectively.
Tyrosine kinase-IN-1 Chemical Structure
 BCP30849 Tyrosine kinase-IN-1 705946-27-6
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.
ZD-4190 Chemical Structure
 BCP30854 ZD-4190 413599-62-9
ZD-4190 is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the treatment of cancer.
Vorolanib Chemical Structure
 BCP30430 Vorolanib 1013920-15-4
Vorolanib, also known as CM-082 and X-82, is small molecule dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs) with antiangiogenic and antineoplastic activities.
ODM-203 HCl Chemical Structure
 BCP30289 ODM-203 HCl ODM-203hcl
ODM-203 is a potent, selective, dual inhibitor of FGFR and VEGFR tyrosine kinases with approximately equal potency towards recombinant FGFR1, 2, 3 and 4, as well as VEGFR1, 2 and 3 (IC50=5-35 nM).
EG00229 Chemical Structure
 BCP30286 EG00229 1018927-63-3
EG00229 is a Neuropilin 1 (NRP1) receptor antagonist. EG00229 inhibits VEGFA binding to NRP1.
Bevacizumab Chemical Structure
 BCP07998 Bevacizumab 216974-75-3
Bevacizumab is a recombinant humanized monoclonal antibody that blocks angiogenesis by inhibiting vascular endothelial growth factor A (VEGF-A).
AAL-993 Chemical Structure
 BCP18097 AAL-993 269390-77-4
AAL-993 is a highly potent inhibitor of VEGFR-1 (IC50 =130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM).
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