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PLK

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PLK

Chemical Structure Cat. No. Product Name CAS No.
GW843682X Chemical Structure
BCP27639 GW843682X 660868-91-7
GW843682X is a cell-permeable thiophene-benzimidazole compound that acts a selective PLK1 and PLK3 inhibitor with IC50s of 2.2 nM(PLK1) and 9.1 nM(PLK3).
DAP-81 Chemical Structure
BCP29728 DAP-81 794466-17-4
DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules.
CFI-400437 Chemical Structure
BCP29569 CFI-400437 1247000-76-5
CFI-400437 is potent against PLK4 (IC50 = 0.6 nM) and selective against other members of the PLK family (>10 uM).
ON1231320 Chemical Structure
BCP19609 ON1231320 131247-39-8
ON1231320, also known as GBO-006, is a Polo-like kinase 2 (PLK2) inhibitor.
SBE 13 hydrochloride Chemical Structure
BCP23836 SBE 13 hydrochloride 1052532-15-6
SBE13 Hydrochloride is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; poorly inhibits Plk2 (IC50>66 μM) or Plk3 (IC50=875 nM).
Mps1-in-2 Chemical Structure
BCP19164 Mps1-in-2 1228817-38-6
Mps1-IN-2 is a potent Mps1 kianse inhibitor with IC50 value of 145 nM.
RO3280 Chemical Structure
BCP07189 RO3280 1062243-51-9
Ro5203280 is a small-molecular PLK1 inhibitor that is structurally similar to BI2536, but with improved activity.
TAK960 Chemical Structure
BCP09476 TAK960 1137868-52-0
TAK-960 is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM at 10 μM ATP; also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively.
TAK-960 hydrochloride Chemical Structure
BCP28992 TAK-960 hydrochloride 1137868-96-2
TAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM at 10 μM ATP; also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively.
CFI-400945 fumarate Chemical Structure
BCP25931 CFI-400945 fumarate 1616420-30-4
CFI-400945 fumarate is a potent, selective and orally bioavailable PLK4 inhibitor with a Ki and an IC50 of 0.26 nM and 2.8 nM, respectively.
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