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HER2

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HER2

Chemical Structure Cat. No. Product Name CAS No.
AV-412 Tosylate Chemical Structure
BCP23783 AV-412 Tosylate 451493-31-5
AV-412 (MP412) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.
Pyrotinib Chemical Structure
BCP29458 Pyrotinib 1269662-73-8
Pyrotinib (SHR-1258) is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively.
Pyrotinib maleate Chemical Structure
BCP29462 Pyrotinib maleate 1397922-61-0
Pyrotinib also known as SHR-1258, is an orally bioavailable, dual kinase inhibitor of the epidermal growth factor receptor (EGFR or HER-1) and the human epidermal growth factor receptor 2 (ErbB2 or HER-2), with potential antineoplastic activity.
Epertinib Chemical Structure
BCP29362 Epertinib 908305-13-5
Epertinib is a potent, oral, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively; Epertinib shows potent antitumor activity.
Irbinitinib Chemical Structure
BCP15983 Irbinitinib 937263-43-9
Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity.
Tyrphostin AG 879 Chemical Structure
BCP08354 Tyrphostin AG 879 148741-30-4
Tyrphostin AG 879 is a protein tyrosine kinase inhibitor with potent effects on TrkA.
BMS-599626 HCl Chemical Structure
BCP01780 BMS-599626 HCl 873837-23-1
BMS-599626 (BMS-599626; AC480) is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively.
BMS-599626 Chemical Structure
BCP19580 BMS-599626 714971-09-2
AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc.
Mubritinib Chemical Structure
BCP02837 Mubritinib 366017-09-6
Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk.
CUDC-101 Chemical Structure
BCP01935 CUDC-101 1012054-59-9
CUDC-101 is a potent multitargeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.
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