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GPCR/G Protein
Endothelin Receptor

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Endothelin Receptor

Chemical Structure Cat. No. Product Name CAS No.
Aprocitentan Chemical Structure
BCP28125 Aprocitentan 1103522-45-7
Aprocitentan is the major and pharmacologically active metabolite of macitentan, which is dual ETA/ETB antagonist designed for tissue targeting.
BQ-123 Chemical Structure
BCP29354 BQ-123 136553-81-6
BQ-123 is a elective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively).
Ro 46-2005 Chemical Structure
BCP17756 Ro 46-2005 150725-87-4
Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.
IRL-1620 Chemical Structure
BCP09112 IRL-1620 142569-99-1
IRL-1620, also known as SPI-1620, is an endothelin B receptor agonist.
Sitaxsentan sodium Chemical Structure
BCP08362 Sitaxsentan sodium 210421-74-2
Sitaxsentan sodium (TBC11251 sodium salt) is an orally active, highly selective antagonist of endothelin A receptors.
Ambrisentan Chemical Structure
BCP22426 Ambrisentan 177036-94-1
Ambrisentan is a selective ET type A receptor (ETAR) antagonist.
Endothelin-1 Acetate Chemical Structure
BCP27613 Endothelin-1 Acetate 117399-94-7
Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB.
Bosentan Chemical Structure
BCP05202 Bosentan 147536-97-8
Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
Atrasentan Chemical Structure
BCP17322 Atrasentan 173937-91-2
Atrasentan is an endothelin receptor antagonist with IC50 of 0.0551 nM for ETA.
Atrasentan hydrochloride Chemical Structure
BCP19490 Atrasentan hydrochloride 195733-43-8
Atrasentan Hcl(A-147627) is an endothelin antagonist receptor (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer.
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