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FLT3

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FLT3

Chemical Structure Cat. No. Product Name CAS No.
Donafenib Chemical Structure
 BCP34023 Donafenib 1130115-44-4
Donafenib is an oral multikinase inhibitor that targets Raf kinase and receptor tyrosine kinases with potential anticancer acivity. Donafenib is under clinical trials in China in patients with advanced hepatocellular carcinoma (HCC).
FF-10101 Chemical Structure
 BCP23613 FF-10101 FF-10101
FF-10101 is a novel irreversible FLT3 inhibitor, shows excellent efficacy against AML cells with FLT3 mutations
MRX-2843 Chemical Structure
 BCP30180 MRX-2843 1429882-07-4
MRX-2843 is an orally available small-molecule inhibitor of both MERTK and FLT3.
TG46 Chemical Structure
 BCP28052 TG46 936091-15-5
TG-46 is an inhibitor of JAK2, FLT3, RET, JAK3.
AST-487 Chemical Structure
 BCP21589 AST-487 630124-46-8
AST 487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM.
CCT241736 Chemical Structure
 BCP29563 CCT241736 1402709-93-6
CCT241736 is a novel, orally bioavailable, imidazo[4,5-b]pyridine derivative discovered at our Institute, highly selective for FLT3 and Aurora kinases with an S(10) selectivity score using KINOMEscan™ technology of 0.057 (fraction of 386 non-mutant kinases inhibited >90% when screened at 1 uM of CCT241736; San Diego, CA).
STK321130 Chemical Structure
 BCP15254 STK321130 923562-23-6
STK321130, also known as FLT3-IN-2, is potent FLT3 inhibitor.
SU5614 Chemical Structure
 BCP16040 SU5614 1055412-47-9
SU5614 is a potent and selective FLT3 inhibitor.
JNJ-47117096 Chemical Structure
 BCP26188 JNJ-47117096 1610586-62-3
MELK-T1 is a potent and selective inhibitor of protein kinase MELK. MELK-T1 decreases DNA-damage tolerance in proliferating cancer cells.
AZD-2932 Chemical Structure
 BCP07984 AZD-2932 883986-34-3
AZD2932 is a new series of quinazoline ether inhibitor which potently inhibits VEGFR-2 and PDGFR with IC50s of 4 nM/8 nM/ 7 nM for PDGFRβ/VEGFR-2/Flt-3.
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