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FLT3

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FLT3

Chemical Structure Cat. No. Product Name CAS No.
MRX-2843 Chemical Structure
 BCP30180 MRX-2843 1429882-07-4
MRX-2843 is an orally available small-molecule inhibitor of both MERTK and FLT3.
TG46 Chemical Structure
 BCP28052 TG46 936091-15-5
TG-46 is an inhibitor of JAK2, FLT3, RET, JAK3.
SB1317 Chemical Structure
 BCP27919 SB1317 1204918-72-8
SB1317 is a potent inhibitor of CDK2, JAK2, and FLT3 for the treatment of cancer, with IC50 of 13, 73, and 56 nM for CDK2, JAK2 and FLT3, respectively.
AST-487 Chemical Structure
 BCP21589 AST-487 630124-46-8
AST 487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM.
CCT241736 Chemical Structure
 BCP29563 CCT241736 1402709-93-6
CCT241736 is a novel, orally bioavailable, imidazo[4,5-b]pyridine derivative discovered at our Institute, highly selective for FLT3 and Aurora kinases with an S(10) selectivity score using KINOMEscan™ technology of 0.057 (fraction of 386 non-mutant kinases inhibited >90% when screened at 1 uM of CCT241736; San Diego, CA).
STK321130 Chemical Structure
 BCP15254 STK321130 923562-23-6
STK321130, also known as FLT3-IN-2, is potent FLT3 inhibitor.
SU5614 Chemical Structure
 BCP16040 SU5614 1055412-47-9
SU5614 is a potent and selective FLT3 inhibitor.
JNJ-47117096 Chemical Structure
 BCP26188 JNJ-47117096 1610586-62-3
MELK-T1 is a potent and selective inhibitor of protein kinase MELK. MELK-T1 decreases DNA-damage tolerance in proliferating cancer cells.
AZD-2932 Chemical Structure
 BCP07984 AZD-2932 883986-34-3
AZD2932 is a new series of quinazoline ether inhibitor which potently inhibits VEGFR-2 and PDGFR with IC50s of 4 nM/8 nM/ 7 nM for PDGFRβ/VEGFR-2/Flt-3.
AC-710 Chemical Structure
 BCP14396 AC-710 1351522-04-7
AC710 is a potent, selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM/1.0 nM/1.3 nM/1.0 nM for FLT3/KIT/PDGFRα/PDGFRβ respectively.
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