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Phosphodiesterase/PDE

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Phosphodiesterase/PDE

Chemical Structure Cat. No. Product Name CAS No.
VP3.15 dihydrobromide Chemical Structure
BCP31222 VP3.15 dihydrobromide 1281681-33-1
VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively.
VP3.15 Chemical Structure
BCP31223 VP3.15 1281681-54-6
VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively.
Irsogladine maleate Chemical Structure
BCP21471 Irsogladine maleate 84504-69-8
Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
Oglemilast Chemical Structure
BCP21392 Oglemilast 778576-62-8
Oglemilast is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.
PDE-9 inhibitor Chemical Structure
BCP27644 PDE-9 inhibitor 1082743-70-1
PDE-9 inhibitor is useful for neurodegenerative diseases.
S-(+)-Rolipram Chemical Structure
BCP23388 S-(+)-Rolipram 85416-73-5
(S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer.
Aminophylline Chemical Structure
BCP23387 Aminophylline 317-34-0
Aminophylline is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.
Mardepodect Chemical Structure
BCP23364 Mardepodect 1292799-56-4
PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE.
D159687 Chemical Structure
BCP30853 D159687 1155877-97-6
D159687 is a selective PDE4D inhibitor.
Theophylline Chemical Structure
BCP30664 Theophylline 58-55-9
Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator.
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