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PROTAC

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PROTAC

Chemical Structure Cat. No. Product Name CAS No.
BI-4464 Chemical Structure
BCP30859 BI-4464 1227948-02-8
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC.
Thalidomide Chemical Structure
BCP19772 Thalidomide 50-35-1
Thalidomide is initially promoted as a sedative, inhibits ereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.
E3 ligase Ligand 1 Chemical Structure
BCP30724 E3 ligase Ligand 1 1948273-03-7
E3 ligase Ligand 1 is a Ligand for E3 Ligase extracted from patent WO/2017/030814A1 compound example 202, used in PROTAC technology.
E3 ligase Ligand 4 Chemical Structure
BCP30586 E3 ligase Ligand 4 835616-60-9
E3 ligase Ligand 4 is a precursor to Pomalidomide-based PROTACs.
VL285 Chemical Structure
BCP30479 VL285 1448188-57-5
VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins.
Protein degrader 1 Chemical Structure
BCP25134 Protein degrader 1 1448297-52-6
Protein degrader 1 is a potent and selective protein degrader.
Protein degrader 1 hydrochloride Chemical Structure
BCP25135 Protein degrader 1 hydrochloride 1448189-80-7
Protein degrader 1 hydrochloride is used in the synthesis of HaloPROTACs.
dBET1 Chemical Structure
BCP25962 dBET1 1799711-21-9
dBET1 is a potent BRD4 protein degrader based on PROTAC technology with an EC50 of 430 nM.
ARV-825 Chemical Structure
BCP19950 ARV-825 1818885-28-7
ARV-825 is a BRD4 Inhibitor based on PROTAC technology.
E3 ligase Ligand 2 Chemical Structure
BCP20021 E3 ligase Ligand 2 5054-59-1
E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology.
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