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Syk

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Syk

Chemical Structure Cat. No. Product Name CAS No.
R 112 Chemical Structure
BCP20695 R 112 575474-82-7
R112 is an ATP-competitive inhibitor of Syk kinase with a Ki of 96 nM. R112 inhibits Syk kinase activity with an IC50 of 226 nM.
RO 9021 Chemical Structure
BCP17963 RO 9021 1446790-62-0
RO9021 is an oral, ATP-competative and selective inhibitor of spleen tyrosine kinase (SYK). RO-9021 potently inhibited SYK kinase activity with an average IC50 of 5.6 nM.
PRT-060318 Chemical Structure
BCP13151 PRT-060318 1194961-19-7
PRT-060318 (PRT318,P142–76) is a novel selective inhibitor of the tyrosine kinase Syk with an IC50 of 4 nM.
BAY 61-3606 dihydrochloride Chemical Structure
BCP24726 BAY 61-3606 dihydrochloride 648903-57-5
AY 61-3606 (dihydrochloride) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase (IC50=10 nM) with no inhibitory effect on Btk, Fyn, Itk, Lyn, and Src.
Cerdulatinib HCl salt Chemical Structure
BCP25893 Cerdulatinib HCl salt 1369761-01-2
Cerdulatinib is a novel, orally available, ATP-competitive JAK and SYK inhibitor that demonstrates selective inhibition of TYK2 and SYK with an IC50 of 0.5 nM and 32 nM.
PRT062607 HCl Chemical Structure
BCP09980 PRT062607 HCl 1370261-97-4
PRT062607 Hcl is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.
 TAK-659 2HCl  Chemical Structure
BCP28885 TAK-659 2HCl 1312691-41-0
TAK-659 is a potent spleen tyrosine kinase (syk) inhibitor under the development of Takeda Oncology, with potential anti-inflammatory, immunomodulating, and antineoplastic activities.
 TAK-659 hydrochloride Chemical Structure
BCP28884 TAK-659 hydrochloride 1952251-28-3
TAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM.
TAK-659 Chemical Structure
BCP28883 TAK-659 1312691-33-0
TAK-659 is an inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities.
R788 sodium Chemical Structure
BCP02850 R788 sodium 1025687-58-4
R788 (Fostamatinib) disodium, a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
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