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PARP

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PARP

Chemical Structure Cat. No. Product Name CAS No.
Venadaparib Chemical Structure
 BCP42946 Venadaparib 1681017-83-3
Venadaparib is an antineoplastic.Venadaparib is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively.
RBN012759 Chemical Structure
 BCP42877 RBN012759 2360851-29-0
RBN012759 is a potent and selective inhibitor of PARP14 with IC50 of <3 nM and 5 nM for human catalytic domain and mouse catalytic domain, respectively. RBN012759 contributes to anti-tumor immune response.
AZD-5305 Chemical Structure
 BCP41765 AZD-5305 2589531-76-8
AZD5305 is a potent and oral active, second-generation PARP (highly selective PARP1) inhibitor.
DR2313 Chemical Structure
 BCP40859 DR2313 284028-90-6
DR 2313 has been found to be a PARP-1/PARP-2 inhibitor and could exhibit neuroprotective avtivities as well as reduce cortical infarct volume in focal ischemia.
Fuzuopali Chemical Structure
 BCP38585 Fuzuopali 1358715-18-0
Fluzoparib is a selective poly [ADP-ribose] polymerase 1 (PARP1) and poly [ADP-ribose] polymerase 2 inhibitor (PARP2).
TFLLR-NH2 Chemical Structure
 BCP38224 TFLLR-NH2 197794-83-5
TFLLR-NH2, derived from the protease-activated receptor-1 (PAR1), is a selective PAR1 agonist with an EC50 of 1.9 μM.
OUL35 Chemical Structure
 BCP37863 OUL35 6336-34-1
OUL35 is a small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.
BGP-15 dihydrochloride Chemical Structure
 BCP24844 BGP-15 dihydrochloride 66611-37-8
BGP-15 is a PARP inhibitor, with an IC50 and a Ki of 120 and 57 μM, respectively.
RBN-2397 Chemical Structure
 BCP33764 RBN-2397 2381037-82-5
RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM).
Rucaparib camsylate Chemical Structure
 BCP25678 Rucaparib camsylate 1327258-57-0
Rucaparib camsylate is a camphorsulfonate salt obtained by reaction of rucaparib with one molar equivalent of (1S,4R)-camphorsulfonic acid. It is an inhibitor of poly (ADP-ribose) polymerase and is used as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation.
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