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Wnt/Stem Cell

Chemical Structure Cat. No. Product Name CAS No.
STAT3-IN-1 Chemical Structure
BCP42674 STAT3-IN-1 2059952-75-7
STAT3-IN-1 is a novel selective and orally active STAT3 inhibitor.
Colivelin Chemical Structure
BCP42673 Colivelin 867021-83-8
Colivelin is a brain-penetrant neuroprotective peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.
BD750 Chemical Structure
BCP42671 BD750 892686-59-8
BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.
SB1317 Chemical Structure
BCP42651 SB1317 1204918-72-8
SB1317 is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. Zotiraciclib may be useful for the treatment of cancer that crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9). It is one of a number of CDK inhibitors under investigation; others targeting CDK9 for the treatment of acute myeloid leukemia include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, with 80 percent of glioblastomas characterized by this property.
Belumosudil mesylate Chemical Structure
BCP41838 Belumosudil mesylate 2109704-99-4
Belumosudil mesylate is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 µM, respectively). Belumosudil (SLx-2119; 40 µM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. Belumosudil (KD025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion.
IWP-O1 Chemical Structure
BCP41115 IWP-O1 2074607-48-8
IWP-O1 is a potent porcupine inhibitor that blocks Wnt signaling in L-Wnt-STF cells with EC50 value of 80 pM. IWP-O1 can affect differentiation of hESC.
I3MT-3 Chemical Structure
BCP40982 I3MT-3 459420-09-8
I3MT-3 is a novel potent and selective inhibitor of 3-mercaptopyruvate sulfurtransferase (3-MST).
SHR0302 Chemical Structure
BCP34833 SHR0302 1445987-21-2
SHR0302 is a novel potent JAK inhibitor, blocking JAK/STAT3 signaling, suppressing proliferation, migration and collagen production, and inducing the apoptosis of hepatic stellate cells.
SI-109 Chemical Structure
BCP40461 SI-109 2429877-30-3
SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM).
PRI-724 Chemical Structure
BCP39699 PRI-724 1198780-43-6
PRI-724, an isomer or enantiomer of ICG-001, is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity.
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