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Wnt/Stem Cell

Chemical Structure Cat. No. Product Name CAS No.
KY1220 Chemical Structure
BCP34008 KY1220 292168-79-7
KY1220 is a small molecule that simultaneously degrades β-catenin and Ras by inhibition of the Wnt/β-catenin pathway.
PF-06826647 Chemical Structure
BCP33615 PF-06826647 2127109-84-4
PF-06826647(Tyk2-IN-8) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis.
Alsterpaullone Chemical Structure
BCP33241 Alsterpaullone 237430-03-4
Alsterpaullone, also known as 9-Nitropaullone and NSC 705701, is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β).
STX-0119 Chemical Structure
BCP25956 STX-0119 851095-32-4
STX-0119 is a potent STAT3 inhibitor.
Tegatrabetan Chemical Structure
BCP32893 Tegatrabetan 1227637-23-1
Tegatrabetan is a β-Catenin antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1).
Y-27632  Dihydrochloride Hydrate Chemical Structure
BCP26044 Y-27632 Dihydrochloride Hydrate 331752-47-7
Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively, which primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation.
CHIR-99021 trihydrochloride Chemical Structure
BCP26069 CHIR-99021 trihydrochloride 1782235-14-6
CHIR99021 is an orally active and potent GSK3 inhibitor. CHIR-73911 exhibited GSK3 IC50 in the low nanomolar range and excellent selectivity. CHIR-73911 activates glycogen synthase in insulin receptorexpressing CHO-IR cells and primary rat hepatocyte
NVS-ZP7-4 Chemical Structure
BCP32718 NVS-ZP7-4 2349367-89-9
NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.
iCRT3 Chemical Structure
BCP32691 iCRT3 901751-47-1
iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription.
Longdaysin Chemical Structure
BCP32583 Longdaysin 1353867-91-0
Longdaysin is a novel inhibitor of CK1, ERK2, and CDK7 kinases.
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