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PKC

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PKC

Chemical Structure Cat. No. Product Name CAS No.
Bisindoylmaleimide X Chemical Structure
BCP25395 Bisindoylmaleimide X 1241725-89-2
Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).
LXS-196 2HCl Chemical Structure
BCP30427 LXS-196 2HCl LXS-196HCl
LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. It can be used for the treatment of uveal melanoma.
MDK-8650 Chemical Structure
BCP30378 MDK-8650 736048-65-0
MDK-8650 is a selective PKC-θinhibitor, with an IC50 of 12 nM.
PKC-IN-1 Chemical Structure
BCP10410 PKC-IN-1 1046787-18-1
PKC-IN-1 has been found to be a PKCβII inhibitor that probably has biological activity in antineoplastic studies.
TX-1918 Chemical Structure
BCP16358 TX-1918 503473-32-3
TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM).
UCN-01 Chemical Structure
BCP14345 UCN-01 112953-11-4
UCN-01 (7-hydroxystaurosporine) acts as an inhibitor against many phosphokinases, such as the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases.
UCN-02 Chemical Structure
BCP14344 UCN-02 121569-61-7
Prostratin Chemical Structure
BCP29895 Prostratin 60857-08-1
Prostratin is a protein kinase C activator. Inhibits growth and induces differentiation of AML cell lines.
Ingenol-3-angelate Chemical Structure
BCP10402 Ingenol-3-angelate 75567-37-2
Ingenol-3-angelate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.
D-erythro-Sphingosine Chemical Structure
BCP24874 D-erythro-Sphingosine 123-78-4
D-erythro-Sphingosine is a inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.
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