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Notch

Chemical Structure Cat. No. Product Name CAS No.
JI051 Chemical Structure
BCP31018 JI051 2234281-75-3
JI051 is an inhibitor of the cancer-associated transcription factor Hes1 via the PHB2 chaperone. JI051 stabilizes PHB2's interaction with Hes1 outside the nucleus, inducing G2/M cell cycle arrest.
BMS-906024 Chemical Structure
BCP18995 BMS-906024 1401066-79-2
BMS-906024 is a novel, potent Notch receptor inhibitor .
BMS-708163 Chemical Structure
BCP01770 BMS-708163 1146699-66-2
BMS-708163 is a γ-secretase inhibitor (GSI) (IC50 =0.3 nM).
BMS-983970 Chemical Structure
BCP25141 BMS-983970 1584713-87-0
BMS-983970 is an oral pan-Notch inhibitor for the treatment of cancer.
Semagacestat Chemical Structure
BCP01878 Semagacestat 425386-60-3
Semagacestat (LY450139) is a γ-secretase blocker with an IC50 of 15 nM.
IMR-1A Chemical Structure
BCP20738 IMR-1A 331862-41-0
IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.
YO-01027 Chemical Structure
BCP02556 YO-01027 209984-56-5
YO-01027 interacts directly with theγ-secretase complex and targets the N-terminal Presenilin fragment.
LY411575 Chemical Structure
BCP02531 LY411575 209984-57-6
LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with withIC50 of 0.39 nM.
LY3039478 Chemical Structure
BCP09264 LY3039478 1421438-81-4
LY3039478 is a novel and potent Notch inhibitor.
FLI-06 Chemical Structure
BCP09289 FLI-06 313967-18-9
FLI-06 is a novel potent and selective small molecule intercepting Notch signaling and the early secretory pathway (EC50 ~2.3 μM), identified by using automated microscopy to monitor the trafficking and processing of a ligand-independent Notch-GFP fusion reporter.
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