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Chemical Structure Cat. No. Product Name CAS No.
CB-103 Chemical Structure
BCP36784 CB-103 218457-67-1
CB-103 is a first-in-class orally active notch signaling pathway inhibitor extracted from patent US9296682B2.
ZLDI-8 Chemical Structure
BCP36163 ZLDI-8 667880-38-8
ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor.
NVS-ZP7-4 Chemical Structure
BCP32718 NVS-ZP7-4 2349367-89-9
NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.
NVS-ZP7-4 Chemical Structure
BCP30754 NVS-ZP7-4 2649367-89-9
NVS-ZP7-4 is a the first-in-class probe for zip7 and the impact of modulating er zinc levels in the notch pathway.
IMR-1 Chemical Structure
BCP25522 IMR-1 310456-65-6
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth in a patient-derived tumor xenograft model.
JI051 Chemical Structure
BCP31018 JI051 2234281-75-3
JI051 is an inhibitor of the cancer-associated transcription factor Hes1 via the PHB2 chaperone. JI051 stabilizes PHB2's interaction with Hes1 outside the nucleus, inducing G2/M cell cycle arrest.
BMS-906024 Chemical Structure
BCP18995 BMS-906024 1401066-79-2
BMS-906024 is a novel, potent Notch receptor inhibitor .
BMS-708163 Chemical Structure
BCP01770 BMS-708163 1146699-66-2
BMS-708163 is a γ-secretase inhibitor (GSI) (IC50 =0.3 nM).
BMS-983970 Chemical Structure
BCP25141 BMS-983970 1584713-87-0
BMS-983970 is an oral pan-Notch inhibitor for the treatment of cancer.
Semagacestat Chemical Structure
BCP01878 Semagacestat 425386-60-3
Semagacestat (LY450139) is a γ-secretase blocker with an IC50 of 15 nM.
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