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Chemical Structure Cat. No. Product Name CAS No.
Jervine Chemical Structure
BCP28214 Jervine 469-59-0
Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.
GSA10 Chemical Structure
BCP24130 GSA10 300833-95-8
GSA-10 is a Smoothened (Smo) receptor agonist (EC50 = 1.2 μM).
SAG Hydrochloride Chemical Structure
BCP26130 SAG Hydrochloride 2095432-58-7
SAG is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with Kd of 59 nM.
Smoothened Agonist HCl Chemical Structure
BCP10857 Smoothened Agonist HCl 364590-63-6
Smoothened Agonist, HCl (SAG), is a highly potent activator of Smo (smoothened).
Halcinonide Chemical Structure
BCP13695 Halcinonide 3093-35-4
Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.
Halcinonide Chemical Structure
BCP18212 Halcinonide 3039-35-4
Halcinonide is a high potency corticosteroid used topically in the treatment of certain skin conditions.
MK-4101 Chemical Structure
BCP18385 MK-4101 935273-79-3
MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. MK-401 Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. MK-4101 showed anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells.
LDE225 HCL Chemical Structure
BCP11861 LDE225 HCL 1218778-76-7
LDE225 is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
Purmorphamine Chemical Structure
BCP03687 Purmorphamine 483367-10-8
Purmorphamine is an activator of Smoothened, and blocks BODIPY-cyclopamine binding to Smo with IC50 of appr 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
SAG Chemical Structure
BCP14694 SAG 912545-86-9
SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM).
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