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Smoothened/Smo

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Smoothened/Smo

Chemical Structure Cat. No. Product Name CAS No.
Saridegib Chemical Structure
BCP25392 Saridegib 1037210-93-7
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.
PF-5274857 Chemical Structure
BCP32887 PF-5274857 1373615-35-0
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.
XL139 mesylate Chemical Structure
BCP23569 XL139 mesylate XL139
BMS-833923, also known as XL-139, is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity.
Jervine Chemical Structure
BCP28214 Jervine 469-59-0
Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.
GSA10 Chemical Structure
BCP24130 GSA10 300833-95-8
GSA-10 is a Smoothened (Smo) receptor agonist (EC50 = 1.2 μM).
SAG Hydrochloride Chemical Structure
BCP26130 SAG Hydrochloride 2095432-58-7
SAG is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with Kd of 59 nM.
Smoothened Agonist HCl Chemical Structure
BCP10857 Smoothened Agonist HCl 364590-63-6
Smoothened Agonist, HCl (SAG), is a highly potent activator of Smo (smoothened).
Halcinonide Chemical Structure
BCP13695 Halcinonide 3093-35-4
Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.
Halcinonide Chemical Structure
BCP18212 Halcinonide 3039-35-4
Halcinonide is a high potency corticosteroid used topically in the treatment of certain skin conditions.
MK-4101 Chemical Structure
BCP18385 MK-4101 935273-79-3
MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. MK-401 Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. MK-4101 showed anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells.
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