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DUB

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DUB

Chemical Structure Cat. No. Product Name CAS No.
6-Thioguanine Chemical Structure
 BCP27718 6-Thioguanine 154-42-7
Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
TCID Chemical Structure
 BCP29983 TCID 30675-13-9
TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.
HBX 41108 Chemical Structure
 BCP08394 HBX 41108 924296-39-9
HBX 41108 is an Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM).
SJB2-043 Chemical Structure
 BCP11060 SJB2-043 63388-44-3
SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor.
NSC 632839 hydrochloride Chemical Structure
 BCP28077 NSC 632839 hydrochloride 157654-67-6
NSC 632839 is an Inhibitor of ubiquitin isopeptidase activity.
LDN-57444 Chemical Structure
 BCP07570 LDN-57444 668467-91-2
Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity (Ki = 0.4 μM).
USP7/USP47 inhibitor Chemical Structure
 BCP27902 USP7/USP47 inhibitor 1247825-37-1
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.
PR-619 Chemical Structure
 BCP07903 PR-619 2645-32-1
PR-619 is a broad-range DUB inhibitor with potential for further development as a chemotherapeutic agent in cancer therapy.
ML364 Chemical Structure
 BCP20769 ML364 1991986-30-1
ML364 is a small molecule inhibitor of the deubiquitinase USP2 with potential anticancer activity.
ML-323 Chemical Structure
 BCP09653 ML-323 1572414-83-5
ML323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively.
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