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Beta secretase

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Beta secretase

Chemical Structure Cat. No. Product Name CAS No.
RG7129 Chemical Structure
BCP23733 RG7129 1310347-50-2
RG7129 is a potent BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM).
Sophoflavescenol Chemical Structure
BCP24815 Sophoflavescenol 216450-65-6
Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC50 of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC50s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.
AZD3839 Chemical Structure
BCP23892 AZD3839 1227163-84-9
AZD3839 is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.
Eslicarbazepine acetate Chemical Structure
BCP07117 Eslicarbazepine acetate 236395-14-5
Voltage-gated sodium channel blocker; significantly blocks excitatory amino acid (glutamate and aspartate) release.
LX-2343 Chemical Structure
BCP28952 LX-2343 333745-53-2
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.
Lanabecestat Chemical Structure
BCP16986 Lanabecestat 1383982-64-6
AZD3293 is a potent and selective orally active, brain-permeable BACE1 inhibitor,currently in development as a potential treatment for early Alzheimer’s disease.
LY2886721 Chemical Structure
BCP02507 LY2886721 1262036-50-9
LY2886721 is a novel potent agent that is used to treat Alzheimer’s Disease in preclinical experiments.
Verubecestat Chemical Structure
BCP15722 Verubecestat 1286770-55-5
MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.
Verubecestat  TFA salt Chemical Structure
BCP26034 Verubecestat TFA salt 2095432-65-6
Verubecestat, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.
LY2811376 Chemical Structure
BCP02221 LY2811376 1194044-20-6
LY2811376 is a BACE1 inhibitor with marked Ab-lowering effects in animal models.
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