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PPAR

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PPAR

Chemical Structure Cat. No. Product Name CAS No.
Lobeglitazone Chemical Structure
 BCP37672 Lobeglitazone 607723-33-1
Lobeglitazone is an agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic activity. Besides its activation of peroxisome proliferator-activated receptor (PPAR) gamma, lobeglitazone is also a potent agonist for PPARalpha.
GW6471 Chemical Structure
 BCP35208 GW6471 880635-03-0
GW 6471 is a potent PPARα antagonist.
LY518674 Chemical Structure
 BCP34904 LY518674 425671-29-0
LY518674 is a potent, selective PPARα antagonist, with an EC50 of 42 nM for human PPARα. LY518674 reduces triglycerides in and increased HDL-C and is used for the treatment of atherosclerosis.
GW6471 Chemical Structure
 BCP33242 GW6471 436159-64-7
GW6471 is a potent PPARα antagonist.
Sipoglitazar Chemical Structure
 BCP33099 Sipoglitazar 342026-92-0
Sipoglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonist, with hypoglycemic activity.
Tesaglitazar Chemical Structure
 BCP23582 Tesaglitazar 251565-85-2
Tesaglitazar is a PPAR agonist potentially for the treatment of type 2 diabetes. The drug had completed several phase III clinical trials, however in May, 2006 AstraZeneca announced that it had discontinued further development.
Pioditazone hydrochloride Chemical Structure
 BCP22942 Pioditazone hydrochloride 112529-15-4
Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.
MK 0767 Chemical Structure
 BCP30796 MK 0767 934017-32-0
MK 0767 is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, has been studied as a potential treatment of type 2 diabetes and dyslipidemia.
MA-0204 Chemical Structure
 BCP30365 MA-0204 2095128-17-7
MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD).
Darglitazone Chemical Structure
 BCP30326 Darglitazone 141200-24-0
Darglitazone is an agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic and anti-inflammatory activities. Darglitazone may be able to abrogate acute cerebral inflammatory responses via its suppression of proinflammatory gene expression.
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