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cFMS

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cFMS

Chemical Structure Cat. No. Product Name CAS No.
PLX5622 Chemical Structure
BCP31350 PLX5622 1303420-67-8
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor, for extended and specific microglial elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals.
JNJ-28312141 Chemical Structure
BCP28018 JNJ-28312141 885692-52-4
JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events.
PLX647 Chemical Structure
BCP15182 PLX647 873786-09-5
PLX647 is a highly specific dual FMS/KIT kinase inhibitor with IC50 of 28/16 nM respectively.
c-FMS inhibitor Chemical Structure
BCP21866 c-FMS inhibitor 885704-21-2
c-FMS inhibitor is a potent, orally active and small-molecule inhibitor of FMS kinase with IC50 value of 0.8 nM.
Edicotinib Chemical Structure
BCP25086 Edicotinib 1142363-52-7
Edicotinib, also known as JNJ-40346527, is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity.
Ki20227(+/-) Chemical Structure
BCP01956 Ki20227(+/-) 623142-96-1
Ki20227 is a c-Fms tyrosine kinase inhibitor.
OSI-930 Chemical Structure
BCP02118 OSI-930 728033-96-3
OSI-930 is an inhibitor of the receptor tyrosine kinases c-Kit (IC50:9.5nM) and VEGFR-2 (IC50:10.1nM).
Pazopanib Chemical Structure
BCP01839 Pazopanib 444731-52-6
Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR-α/β, and c-Kit.
Pazopanib HCl Chemical Structure
BCP02203 Pazopanib HCl 635702-64-6
Pazopanib is a VEGFR inhibitor, IC50 of 10, 30, and 47 nM for VEGFR-1, -2, and -3.
GW2580 Chemical Structure
BCP06918 GW2580 870483-87-7
GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc.
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