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Topoisomerase

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Topoisomerase

Chemical Structure Cat. No. Product Name CAS No.
SN-38 Glucuronide Chemical Structure
BCP24172 SN-38 Glucuronide 121080-63-5
SN38 glucuronide is a pyranoindolizinoquinoline.
Aclarubicin Chemical Structure
BCP21845 Aclarubicin 57576-44-0
Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.
Aldoxorubici Chemical Structure
BCP21580 Aldoxorubici 151038-96-9
Aldoxorubicin, also known as INNO-206 and Doxo-EMCH, is a 6-maleimidocaproyl hydrazone derivative of Doxorubicin, is an albumin binding prodrug.
GENZ-644282 Chemical Structure
BCP20983 GENZ-644282 529488-28-6
Genz-644282 is a non-camptothecin topoisomerase I inhibitor, used for cancer research.
NPC (metabolite) Chemical Structure
BCP24174 NPC (metabolite) 185304-42-1
NPC is a metabolite of irinotecan. Irinotecan is a drug used for the treatment of cancer. Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
Camtobell hydrochloride Chemical Structure
BCP28717 Camtobell hydrochloride 213819-48-8
Camtobell, also known as CKD-602, is the semi-synthetic camptothecin analogue belotecan with potential antitumor activity.
RPR121056 Chemical Structure
BCP24170 RPR121056 181467-56-1
RPR 121056 is an impurity of Irinotecan.
Dp44mT Chemical Structure
BCP15939 Dp44mT 152095-12-0
Dp44mT is an iron chelator, possessing DNA-damaging activity mediated by top2a inhibition.
Bimolane Chemical Structure
BCP18269 Bimolane 74550-97-3
Bimolane is a topoisomerase II inhibitor. Bimolane has been widely used in China as an anti-neoplastic agent and for the treatment of psoriasis.
Camptothecin Chemical Structure
BCP02857 Camptothecin 7689-03-4
Camptothecin is a potent DNA enzyme topoisomerase I inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231.
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