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Topoisomerase

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Topoisomerase

Chemical Structure Cat. No. Product Name CAS No.
Exatecan Chemical Structure
BCP30802 Exatecan 171335-80-1
Exatecan is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
Daunomycinone Chemical Structure
BCP07437 Daunomycinone 21794-55-8
Daunomycinone is the aglycone of daunomycin.
Trovafloxacin Chemical Structure
BCP12644 Trovafloxacin 147059-72-1
Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV.
Aclarubicin Hydrochloride Chemical Structure
BCP07926 Aclarubicin Hydrochloride 75443-99-1
Aclarubicin hydrochloride is an anthracycline produced by Streptomyces galilaeus. It has potent antineoplastic activity.
Rubitecan Chemical Structure
BCP06207 Rubitecan 91421-42-0
Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks.
Ellipticine Hydrochloride Chemical Structure
BCP30117 Ellipticine Hydrochloride 5081-48-1
Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
Silatecan Chemical Structure
BCP19768 Silatecan 220913-32-6
Silatecan is a synthetic, highly lipophilic derivative of camptothecin, with potential antineoplastic and radiosensitizing activities.
9-Hydroxyellipticine Hydrochloride Chemical Structure
BCP11301 9-Hydroxyellipticine Hydrochloride 52238-35-4
9-Hydroxyellipticine, Hydrochloride is a cell-permeable antitumor alkaloid that acts as a potent inhibitor of Topo II (IC50 = 3.3 μM).
SN-38 Glucuronide Chemical Structure
BCP24172 SN-38 Glucuronide 121080-63-5
SN38 glucuronide is a pyranoindolizinoquinoline.
Aclarubicin Chemical Structure
BCP21845 Aclarubicin 57576-44-0
Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.
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