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RAR/RXR

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RAR/RXR

Chemical Structure Cat. No. Product Name CAS No.
Etretinate Chemical Structure
BCP31125 Etretinate 54350-48-0
Etretinate is a RAR and RXR agonist previoulsy used to treat psoriasis. It induces brth defects and suppresses proliferation in cutaneous T-cell lymphoma models.
WYC-209 Chemical Structure
BCP31032 WYC-209 2131803-90-0
WYC-209 is a novel inhibitor of tumor-repopulating cells (trcs), inducing trc apoptosis primarily via the caspase 3 pathway
AGN 190299 Chemical Structure
BCP07476 AGN 190299 118292-41-4
Tazarotenic acid is a thiochromane that is acetylene in which the hydrogens are replaced by 5-carboxypyridin-2-yl and 4,4-dimethylthiochroman-6-yl groups. It is the active form of the prodrug tazarotene. It has a role as a keratolytic drug and a teratogenic agent. It is a monocarboxylic acid, a thiochromane, a retinoid and a member of pyridines.
UVI3003 Chemical Structure
BCP30351 UVI3003 847239-17-2
UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC50s of 0.22 and 0.24 μM, respectively.
LG100268 Chemical Structure
BCP08283 LG100268 153559-76-3
LG100268 is a potent and selective rexinoid and retinoid-X receptor (RXR) agonist. LG100268 binds to the α, β and γ RXR receptors with an IC50 = 3-4 nM and has no activity at the RAR retinoic acid receptors.
HX 531 Chemical Structure
BCP15618 HX 531 188844-34-0
HX 531 is an antagonist of retinoid X receptors.
All-trans-retinal Chemical Structure
BCP14368 All-trans-retinal 116-31-4
All-trans Retinal, also known as Vitamin A aldehyde or Retinaldehyde, is one of the many forms of vitamin A and also the oxidation product of all-trans retinol .
CD1530 Chemical Structure
BCP28865 CD1530 107430-66-0
CD-1530 is a retinoic acid receptor γ selective agonist.
(R)-2-Flurbiprofen Chemical Structure
BCP13426 (R)-2-Flurbiprofen 51543-40-9
(R)-Flurbiprofen is the R-enantiomer of the racemate NSAID Flurbiprofen, (R)-Flurbiprofen inhibits the binding of [3H]9-cis-RA to RXRα LBD with IC50 of 75 μM.
LY2955303 Chemical Structure
BCP20655 LY2955303 1433497-19-8
LY2955303 is a potent and selective RAR-gamma antagonist for the treatment of osteoarthritis pain. LY2955303 has RAR-gamma Ki = 1.09 nM; RAR-alpha Ki > 1700 nM; RAR-beta Ki > 2980 nM. LY2955303 demonstrated good pharmacokinetic properties and was efficacious in the MIA model of osteoarthritis-like joint pain. LY2955303 demonstrated an improved margin to RAR -mediated adverse effects.
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