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Jak/Stat Pathway
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Chemical Structure Cat. No. Product Name CAS No.
STAT3-IN-3 Chemical Structure
BCP43810 STAT3-IN-3 2361304-26-7
STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3).
STAT3-IN-1 Chemical Structure
BCP42674 STAT3-IN-1 2059952-75-7
STAT3-IN-1 is a novel selective and orally active STAT3 inhibitor.
Colivelin Chemical Structure
BCP42673 Colivelin 867021-83-8
Colivelin is a brain-penetrant neuroprotective peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.
BD750 Chemical Structure
BCP42671 BD750 892686-59-8
BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.
SI-109 Chemical Structure
BCP40461 SI-109 2429877-30-3
SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM).
STX-0119 Chemical Structure
BCP25956 STX-0119 851095-32-4
STX-0119 is a potent STAT3 inhibitor.
Niclosamide Chemical Structure
BCP22958 Niclosamide 50-65-7
Niclosamide is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.
Brevilin A Chemical Structure
BCP30982 Brevilin A 16503-32-5
Brevilin A, is a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. antitumour
Golotimod Chemical Structure
BCP24651 Golotimod 229305-39-9
Golotimod is a novel synthetic dipeptide that acts broadly on the Toll-like receptor pathway. It has been shown to stimulate T-lymphocyte differentiation, macrocytic phagocytosis, and specific immune responses, and enhance IL-2 and INF-g production.
MDK-6314 Chemical Structure
BCP28976 MDK-6314 285986-31-4
MDK-6314 is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform.
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