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PDGFR

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PDGFR

Chemical Structure Cat. No. Product Name CAS No.
Sennoside B Chemical Structure
BCP14631 Sennoside B 128-57-4
Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.
Masitinib Mesylate Chemical Structure
BCP30695 Masitinib Mesylate 1048007-93-7
Masitinib Mesylate is a potent and selective tyrosine kinase inhibitor that targets KIT.
Olaratumab Chemical Structure
BCP30495 Olaratumab 1024603-93-7
Olaratumab is a monoclonal antibody for the treatment of solid tumors.
Vorolanib Chemical Structure
BCP30430 Vorolanib 1013920-15-4
Vorolanib, also known as CM-082 and X-82, is small molecule dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs) with antiangiogenic and antineoplastic activities.
N-Desethyl Sunitinib Chemical Structure
BCP20914 N-Desethyl Sunitinib 356068-97-8
N-Desethyl Sunitinib is a metabolite of sunitinib.
JNJ-10198409 Chemical Structure
BCP08276 JNJ-10198409 627518-40-5
JNJ-10198409, also known as RWJ-540973, is an inhibitor of PDGF-BB tyrosine kinase with an IC50 value of 4.2 nM.
SU 4312 Chemical Structure
BCP20743 SU 4312 5812-07-7
Potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). Selective over EGFR and c-Src tyrosine kinases.
DCC-2618 Chemical Structure
BCP29218 DCC-2618 1442472-39-0
DCC-2618 is a pan-KIT and PDGFRA inhibitor, and has antitumor activity.
SIM010603 Chemical Structure
BCP25213 SIM010603 1032265-67-0
SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor.
TG 100801 Hydrochloride Chemical Structure
BCP25254 TG 100801 Hydrochloride 1018069-81-2
TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
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