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GPCR/G Protein
S1P Receptor

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S1P Receptor

Chemical Structure Cat. No. Product Name CAS No.
VPC 23019 Chemical Structure
BCP37989 VPC 23019 449173-19-7
VPC 23019 is an aryl amide-containing S1P analog that acts as a competitive antagonist, inhibit S1P-induced migration of thyroid cancer cells, ovarian cancer cells, and neural stem cells.
NIBR 0213 Chemical Structure
BCP37856 NIBR 0213 1233332-14-3
NIBR 0213 is a potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis.
CYM50308 Chemical Structure
BCP37809 CYM50308 1345858-76-5
CYM50308 is a novel agonist of SIP4 (EC50 = 56 nM) that displays 37-fold selectivity against S1P5 (EC50 = 2.1 μM) and no appreciable activity over the S1P1-3 subtypes at concentrations up to 25 μM.
Ozanimod hydrochloride Chemical Structure
BCP37091 Ozanimod hydrochloride 1618636-37-5
Ozanimod is a selective sphingosine 1 phosphate receptor modulators and methods which may be useful in the treatment of S1P1-​associated diseases.
Sphingosine 1-phosphate Chemical Structure
BCP36245 Sphingosine 1-phosphate 26993-30-6
Sphingosine-1-phosphate is an endogenous second messenger that inhibits cell proliferation and motility, and Ca2+ mobilization to prevent tumor cell metastasis. Sphingosine-1-phosphate acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12.
Ex 26 Chemical Structure
BCP36141 Ex 26 1233332-37-0
Ex 26 is a novel potent and selective S1P1 receptor antagonist.
Siponimod fumarate Chemical Structure
BCP25217 Siponimod fumarate 1234627-85-0
Siponimod is a a potent and orally selective S1P Receptor Modulator with EC50 value of 0.39nM for S1P1 receptors and 0.98nM for S1P5 receptors, respectively.
SEW​2871 Chemical Structure
BCP35038 SEW​2871 256414-75-2
SEW2871 is a highly selective, orally active S1P1 agonist with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood and has therapeutic implications in contexts of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses.
SAR-100842 Chemical Structure
BCP34736 SAR-100842 1195941-38-8
SAR-100842 is a lysophaphatidic acid 1 (LPA1/Edg-2) receptor inhibitor.
AUY954 Chemical Structure
BCP33492 AUY954 820240-77-5
AUY-954 is a potent and selective S1P(1) modulator.
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