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GPCR/G Protein
S1P Receptor

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S1P Receptor

Chemical Structure Cat. No. Product Name CAS No.
MUN96006 Chemical Structure
BCP42260 MUN96006 2130996-00-6
MUN96006 is an antagonists of sphingosine-​1-​phosphate (S1P) receptor for prophylaxis and​/or treatment of diseases including fibrotic, inflammatory, autoimmune, metabolic, cardiovascular, and​/or proliferative diseases.
S1P1 Agonist III Chemical Structure
BCP41026 S1P1 Agonist III 1324003-64-6
S1P1 Agonist III is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist.
PF429242 dihydrochloride Chemical Structure
BCP39849 PF429242 dihydrochloride 2248666-66-0
PF 429242 is a reversible and competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM), a transcriptional regulators of cholesterol, fatty acid, and glucose metabolism.
W146 trifluoroacetate salt Chemical Structure
BCP38982 W146 trifluoroacetate salt 909725-62-8
W146 is a potent, selective S1P1 antagonist with Ki of 18 nM, displays no effect at S1P2, S1P3 or S1P5, enhances capillary leakage and restores lymphocyte egress in vivo. .
RP101075 Chemical Structure
BCP38980 RP101075 1306760-73-5
RP101075 is a metabolite of ozanimod (GLXC-10658), exhibiting a similar specificity profile as ozanimod at the S1P receptor family in vitro and pharmacodynamic profile in vivo
VPC 23019 Chemical Structure
BCP37989 VPC 23019 449173-19-7
VPC 23019 is an aryl amide-containing S1P analog that acts as a competitive antagonist, inhibit S1P-induced migration of thyroid cancer cells, ovarian cancer cells, and neural stem cells.
NIBR 0213 Chemical Structure
BCP37856 NIBR 0213 1233332-14-3
NIBR 0213 is a potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis.
CYM50308 Chemical Structure
BCP37809 CYM50308 1345858-76-5
CYM50308 is a novel agonist of SIP4 (EC50 = 56 nM) that displays 37-fold selectivity against S1P5 (EC50 = 2.1 μM) and no appreciable activity over the S1P1-3 subtypes at concentrations up to 25 μM.
Ozanimod hydrochloride Chemical Structure
BCP37091 Ozanimod hydrochloride 1618636-37-5
Ozanimod is a selective sphingosine 1 phosphate receptor modulators and methods which may be useful in the treatment of S1P1-​associated diseases.
Sphingosine 1-phosphate Chemical Structure
BCP36245 Sphingosine 1-phosphate 26993-30-6
Sphingosine-1-phosphate is an endogenous second messenger that inhibits cell proliferation and motility, and Ca2+ mobilization to prevent tumor cell metastasis. Sphingosine-1-phosphate acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12.
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