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Ras/Rho

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Ras/Rho

Chemical Structure Cat. No. Product Name CAS No.
MRTX1133 Chemical Structure
 BCP43012 MRTX1133 2621928-55-8
MRTX1133 is a potent, selective and reversible inhibitor of KRAS G12D, binds to and inhibits mutant KRAS protein in both its active and inactive states.
CID44216842 Chemical Structure
 BCP42675 CID44216842 1222513-26-9
CID44216842 is a potent Cdc42-selective guanine nucleotide binding lead inhibitor.
BAY-293 Chemical Structure
 BCP31742 BAY-293 2244904-70-7
BAY-293 is a potent SOS1 inhibitor that blocks RAS activation via disruption of the RAS-SOS1 interaction. BAY-293) selectively inhibits the KRAS-SOS1 interaction with an IC50 of 21 nM and is a valuable chemical probe for future investigations.
K-Ras-PDEδ-IN-1 Chemical Structure
 BCP36418 K-Ras-PDEδ-IN-1 1841464-21-8
K-Ras-PDEδ-IN-1 is a novel and potent competitive K-Ras-PDEδ inhibitor.
KRAS inhibitor-9 Chemical Structure
 BCP36417 KRAS inhibitor-9 300809-71-6
KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS.
K-Ras G12C-IN-3 Chemical Structure
 BCP36435 K-Ras G12C-IN-3 1629268-19-4
K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.
K-Ras G12C-IN-1 Chemical Structure
 BCP36416 K-Ras G12C-IN-1 1629265-17-3
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
K-Ras Degrader-1 Chemical Structure
 BCP36377 K-Ras Degrader-1 2378258-52-5
PROTAC K-Ras Degrader-1 (Compound 518) is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells.
KRAS G12C inhibitor 14 Chemical Structure
 BCP36376 KRAS G12C inhibitor 14 2349393-95-7
KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM.
ML162 Chemical Structure
 BCP34808 ML162 1035072-16-2
ML162 is a small-molecule probe that selectively kills cells induced to express mutant RAS.
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