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Ras/Rho

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Ras/Rho

Chemical Structure Cat. No. Product Name CAS No.
K-Ras(G12C) inhibitor 6 Chemical Structure
 BCP30805 K-Ras(G12C) inhibitor 6 2060530-16-5
K-Ras(G12C) inhibitor 6 is an allosteric, and selective inhibitor of oncogenic K-Ras(G12C).
GGTI-2418 Chemical Structure
 BCP30523 GGTI-2418 501010-06-6
GGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways.
CID-1067700 Chemical Structure
 BCP06876 CID-1067700 314042-01-8
CID-1067700 is a pan GTPase inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki of 13 nM.
MRTX-1257 Chemical Structure
 BCP30448 MRTX-1257 2206736-04-9
MRTX-1257 is an irreversible covalent inhibitor of KRAS G12C with antitumor efficacy.
AMG510 Chemical Structure
 BCP30452 AMG510 2252403-56-6
AMG510 is a potent KRAS G12C covalent inhibitor.
Rhosin Chemical Structure
 BCP21040 Rhosin 1173671-63-0
Rhosin is a specific Rho inhibitor; binds to WT RhoA with an affinity ~0.4 uM Kd; does not interfere with the binding of Cdc42 or Rac1.
Kobe0065 Chemical Structure
 BCP28010 Kobe0065 436133-68-5
Kobe0065 is a novel and effective inhibitor of Ras-Raf interaction, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46±13 μM.
KRas G12C inhibitor 2 Chemical Structure
 BCP29475 KRas G12C inhibitor 2 2206735-61-5
KRas G12C inhibitor 2 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1.
K-Ras(G12C) inhibitor 12 Chemical Structure
 BCP23940 K-Ras(G12C) inhibitor 12 1469337-95-8
K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.32 μM.
ML210 Chemical Structure
 BCP29439 ML210 1360705-96-9
ML-210 is a small molecule that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 71 and 272 nM in HRASG12V-expressing and non-expressing BJeH cells, respectively).
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