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Chemical Structure Cat. No. Product Name CAS No.
BAY-293 Chemical Structure
BCP31742 BAY-293 2244904-70-7
BAY-293 is a potent SOS1 inhibitor that blocks RAS activation via disruption of the RAS-SOS1 interaction. BAY-293) selectively inhibits the KRAS-SOS1 interaction with an IC50 of 21 nM and is a valuable chemical probe for future investigations.
K-Ras-PDEδ-IN-1 Chemical Structure
BCP36418 K-Ras-PDEδ-IN-1 1841464-21-8
K-Ras-PDEδ-IN-1 is a novel and potent competitive K-Ras-PDEδ inhibitor.
KRAS inhibitor-9 Chemical Structure
BCP36417 KRAS inhibitor-9 300809-71-6
KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS.
K-Ras G12C-IN-3 Chemical Structure
BCP36435 K-Ras G12C-IN-3 1629268-19-4
K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.
K-Ras G12C-IN-1 Chemical Structure
BCP36416 K-Ras G12C-IN-1 1629265-17-3
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
K-Ras Degrader-1 Chemical Structure
BCP36377 K-Ras Degrader-1 2378258-52-5
PROTAC K-Ras Degrader-1 (Compound 518) is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells.
KRAS G12C inhibitor 14 Chemical Structure
BCP36376 KRAS G12C inhibitor 14 2349393-95-7
KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM.
ML162 Chemical Structure
BCP34808 ML162 1035072-16-2
ML162 is a small-molecule probe that selectively kills cells induced to express mutant RAS.
AMG-510 Chemical Structure
BCP33368 AMG-510 2296729-00-3
AMG-510 racemate is a racemic mixture of AMB-510, which is a potent KRAS G12C covalent inhibitor. AMG-510 is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. AMG-510 irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. AMG-510 is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors.
GGTI298 hydrochloride Chemical Structure
BCP25545 GGTI298 hydrochloride 205590-41-6
GGTI-298 is a potent geranylgeranyltransferase-I (GGTase-I) inhibitor with potential antitumor actrivity. GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells.
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