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Protease/Metabolic Enzyme
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Nature products
Antibodies
Peptides
Catalysts
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Intermediate
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Raw Materials
Ras/Rho
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP21040 | Rhosin | 1173671-63-0 |
Rhosin is a specific Rho inhibitor; binds to WT RhoA with an affinity ~0.4 uM Kd; does not interfere with the binding of Cdc42 or Rac1.
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BCP28010 | Kobe0065 | 436133-68-5 |
Kobe0065 is a novel and effective inhibitor of Ras-Raf interaction, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46±13 μM.
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BCP29475 | KRas G12C inhibitor 2 | 2206735-61-5 |
KRas G12C inhibitor 2 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1.
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BCP23940 | K-Ras(G12C) inhibitor 12 | 1469337-95-8 |
K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.32 μM.
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BCP29439 | ML210 | 1360705-96-9 |
ML-210 is a small molecule that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 71 and 272 nM in HRASG12V-expressing and non-expressing BJeH cells, respectively).
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BCP24853 | GGTI298 trifluoroacetate salt hydrate | 1217457-86-7 |
GGTI298 Trifluoroacetate is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit Rap1A with IC50 of 3 μM; little effect on Ha-Ras with IC50 of >20 μM.
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BCP24854 | GGTI298 | 180977-44-0 |
GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 μM in vivo, respectively.
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BCP25014 | AR-13324 hydrochloride | 1253952-02-1 |
AR-13324 HCL is a Rho kinase inhibitor with norepinephrine transport inhibitory activity that reduces production of aqueous humor.
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BCP17385 | SCH 51344 | 171927-40-5 |
SCH-51344 is an inhibitor of RAS/RAC-mediated cell morphology pathway.
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BCP29125 | ARS-1620 | 1698055-85-4 |
ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
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