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Ras/Rho

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Ras/Rho

Chemical Structure Cat. No. Product Name CAS No.
Rhosin Chemical Structure
 BCP21040 Rhosin 1173671-63-0
Rhosin is a specific Rho inhibitor; binds to WT RhoA with an affinity ~0.4 uM Kd; does not interfere with the binding of Cdc42 or Rac1.
Kobe0065 Chemical Structure
 BCP28010 Kobe0065 436133-68-5
Kobe0065 is a novel and effective inhibitor of Ras-Raf interaction, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46±13 μM.
KRas G12C inhibitor 2 Chemical Structure
 BCP29475 KRas G12C inhibitor 2 2206735-61-5
KRas G12C inhibitor 2 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1.
K-Ras(G12C) inhibitor 12 Chemical Structure
 BCP23940 K-Ras(G12C) inhibitor 12 1469337-95-8
K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.32 μM.
ML210 Chemical Structure
 BCP29439 ML210 1360705-96-9
ML-210 is a small molecule that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 71 and 272 nM in HRASG12V-expressing and non-expressing BJeH cells, respectively).
GGTI298 trifluoroacetate salt hydrate Chemical Structure
 BCP24853 GGTI298 trifluoroacetate salt hydrate 1217457-86-7
GGTI298 Trifluoroacetate is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit Rap1A with IC50 of 3 μM; little effect on Ha-Ras with IC50 of >20 μM.
GGTI298 Chemical Structure
 BCP24854 GGTI298 180977-44-0
GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 μM in vivo, respectively.
AR-13324 hydrochloride Chemical Structure
 BCP25014 AR-13324 hydrochloride 1253952-02-1
AR-13324 HCL is a Rho kinase inhibitor with norepinephrine transport inhibitory activity that reduces production of aqueous humor.
SCH 51344 Chemical Structure
 BCP17385 SCH 51344 171927-40-5
SCH-51344 is an inhibitor of RAS/RAC-mediated cell morphology pathway.
ARS-1620 Chemical Structure
 BCP29125 ARS-1620 1698055-85-4
ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
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