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RIP

Chemical Structure Cat. No. Product Name CAS No.
Necrostatin 2 racemate Chemical Structure
BCP26072 Necrostatin 2 racemate 852391-15-2
Necrostatin 2 racemate (Nec-1S), the Nec-1 stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect.
GSK2983559 Chemical Structure
BCP23871 GSK2983559 1579965-12-0
GSK2983559 is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor.
PK68 Chemical Structure
BCP32187 PK68 2173556-69-7
PK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90 nM, displays inhibition of RIPK1-dependent necroptosis.
GSK3145095 Chemical Structure
BCP31015 GSK3145095 1622849-43-7
GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM .
GSK547 Chemical Structure
BCP30590 GSK547 2226735-55-1
GSK547 is a highly selective and potent inhibitor of RIP1 kinase that targets RIP1 in vivo.
HS1371 Chemical Structure
BCP30268 HS1371 2158197-70-5
HS-1371 is a potent and ATP-competitive RIP3 inhibitor with an IC50 of 20.8 nM.
GSK481 Chemical Structure
BCP17262 GSK481 1622849-58-4
GSK481 is a Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitor (RIP1 inhibitor).
GSK2983559 Chemical Structure
BCP24219 GSK2983559 1423186-80-4
GSK2983559 is a selective receptor interacting protein 2 (RIP2) kinase inhibitor.
WEHI-345 Chemical Structure
BCP23889 WEHI-345 1354825-58-3
WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM.
GSK583 Chemical Structure
BCP25523 GSK583 1346547-00-9
GSK583 is a Highly Potent and Selective Inhibitor of RIP2 Kinase (RIP2K bing IC50=5 nM; rat in vivo PD IC50 = 50 nM).
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