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IGF1R

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IGF1R

Chemical Structure Cat. No. Product Name CAS No.
NT-157 Chemical Structure
BCP29982 NT-157 1384426-12-3
NT157 is a selective inhibitor of IRS-1/2, IC50 values at sub-micromolar doses (ranging from 0.3 to 0.8 μM), has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival.
TRX818 Chemical Structure
BCP28152 TRX818 1256037-58-7
TRX-818 is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities
AZD-9362 Chemical Structure
BCP25048 AZD-9362 1905412-80-7
AZD-9362 is dual IGF-IR/InsR inhibitor.
PQ 401 Chemical Structure
BCP06474 PQ 401 196868-63-0
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
NVP-ADW742 Chemical Structure
BCP01826 NVP-ADW742 475489-15-7;475488-23-4
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
XL-228 Chemical Structure
BCP08143 XL-228 898280-07-4
XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases.
BMS-536924 Chemical Structure
BCP02116 BMS-536924 468740-43-4
BMS-536924 is a small molecule ATP-competitive IGF-IR kinase inhibitor with with an IC50 of 80 nM.
AZ7550 Chemical Structure
BCP20939 AZ7550 1421373-99-0
AZ7550 is a circulating active metabolite of AZD9291 and can reduce the activity of IGF1R with an IC50 of 1.6 μM.
BMS-754807 Chemical Structure
BCP01926 BMS-754807 1001350-96-4
BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity.
Picropodophyllin Chemical Structure
BCP18482 Picropodophyllin 477-47-4
AXL1717 is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with IC50 of 1 nM.
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