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IGF1R

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IGF1R

Chemical Structure Cat. No. Product Name CAS No.
SBI-477 Chemical Structure
BCP42957 SBI-477 781628-99-7
SBI-477 is an insulin signaling inhibitor that deactivates the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). SBI-477 inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes.
GSK 621659A Chemical Structure
BCP25985 GSK 621659A 475489-15-7
GSK 552602A is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC50 of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC50 of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells.
Ginsenoside-Rg5 Chemical Structure
BCP10278 Ginsenoside-Rg5 186763-78-0
Ginsenoside Rg5 is a triterpenoid saponin. It has a role as a metabolite.
NT-157 Chemical Structure
BCP29982 NT-157 1384426-12-3
NT157 is a selective inhibitor of IRS-1/2, IC50 values at sub-micromolar doses (ranging from 0.3 to 0.8 μM), has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival.
TRX818 Chemical Structure
BCP28152 TRX818 1256037-58-7
TRX-818 is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities
AZD-9362 Chemical Structure
BCP25048 AZD-9362 1905412-80-7
AZD-9362 is dual IGF-IR/InsR inhibitor.
PQ 401 Chemical Structure
BCP06474 PQ 401 196868-63-0
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
NVP-ADW742 Chemical Structure
BCP01826 NVP-ADW742 475488-23-4
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
XL-228 Chemical Structure
BCP08143 XL-228 898280-07-4
XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases.
BMS-536924 Chemical Structure
BCP02116 BMS-536924 468740-43-4
BMS-536924 is a small molecule ATP-competitive IGF-IR kinase inhibitor with with an IC50 of 80 nM.
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