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Phosphatase

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Phosphatase

Chemical Structure Cat. No. Product Name CAS No.
TNO155 Chemical Structure
BCP33299 TNO155 1801765-04-7
TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors.
SPI112 Chemical Structure
BCP32787 SPI112 1051387-90-6
SPI-112, the SPI-112 methyl ester analog was able to inhibit cellular Shp2 PTP activity.
KY-226 Chemical Structure
BCP32729 KY-226 1621673-53-7
KY-226 is a potent, selective, orally active and allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 0.25 μM, and without PPARγ agonist activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. KY-226 also protects neurons from cerebral ischemic injury.
NSC 95397 Chemical Structure
BCP32686 NSC 95397 93718-83-3
NSC-95397 is a novel CDC25B inhibitor, inhibiting influenza A virus replication in dose-dependent fashion. NSC95397 prevents the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression. NSC-95397 triggers apoptosis of tumor cells and is thus considered for the treatment of malignancy.
SPI-112Me Chemical Structure
BCP32620 SPI-112Me 1243685-62-2
SPI-112Me is a prodrug for SPI-112, which preferentially inhibits the PTPase activity of Shp2 over Shp1 and PTP1B by a factor of 20 in cell-free assays.
CPDA Chemical Structure
BCP32596 CPDA 1415834-63-7
CPDA is a novel potent SH2 domain-containing inositol phosphatase 2 (SHIP2) inhibitor.
Rilapladib Chemical Structure
BCP31473 Rilapladib 412950-08-4
Rilapladib is a selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) inhibitor with an IC50 of 230 pM.
TPI-1 Chemical Structure
BCP28977 TPI-1 79756-69-7
TPI-1 is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM.
SMAP Chemical Structure
BCP30730 SMAP 1809427-19-7
SMAP is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth.
RMC4550 Chemical Structure
BCP30530 RMC4550 2172651-73-7
RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.
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