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Raf

Chemical Structure Cat. No. Product Name CAS No.
Belvarafenib Chemical Structure
BCP31233 Belvarafenib 1446113-23-0
Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.
RO5126766 Chemical Structure
BCP21067 RO5126766 946128-88-7
Ro 5126766 is a first-in-class dual MEK/RAF inhibitor that allosterically inhibits BRAFV600E, CRAF, MEK, and BRAF (IC50: 8.2, 56, 160 nM, and 190 nM, respectively).
LUT-014 Chemical Structure
BCP30636 LUT-014 2274819-46-2
LUT014 is a topical B-Raf Inhibitor, a proprietary, first-in-class, small molecule allowing administration of EGFR (Epidermal Growth Factor Receptor) Inhibitors to patients without interruptions caused by typical cutaneous side effects
LXH254 HCl Chemical Structure
BCP30244 LXH254 HCl LXH254HCl
LXH254 is a potent CRAF inhibitor extracted from patent WO2018051306A1, Compound A. LXH254 also is a potent BRAF inhibitor.
B-Raf inhibitor 1 dihydrochloride Chemical Structure
BCP29713 B-Raf inhibitor 1 dihydrochloride 1191385-19-9
B-Raf inhibitor 1 dihydrochloride is a novel potent and selective B-Raf inhibitor.
Takeda-6d Chemical Structure
BCP29579 Takeda-6d 1125632-93-0
Takeda-6d has potent inhibitory activity in both B-RAF with an IC50 of 7.0 nM and VEGFR2 with an IC50 of 2.2 nM.
PF-04880594 Chemical Structure
BCP21016 PF-04880594 1111636-35-1
PF-04880594 is a RAF inhibitor, which induces ERK phosphorylation and RAF dimerization in those epithelial tissues that undergo hyperplasia.
B-Raf-IN-1 Chemical Structure
BCP28151 B-Raf-IN-1 950736-05-7
B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM; equipotent against c-Raf (IC50= 25 nM).
HA-15 Chemical Structure
BCP28914 HA-15 1609402-14-3
HA15 displayed anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.
LXH254 Chemical Structure
BCP29080 LXH254 1800398-38-2
LXH254 is a potent CRAF inhibitor extracted from patent WO2018051306A1, Compound A. LXH254 also is a potent BRAF inhibitor.
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