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Protease/Metabolic Enzyme
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Nature products
Antibodies
Peptides
Catalysts
Impurities
Intermediate
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Raw Materials
Src/Bcr Abl
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP09491 | 1 NM-PP1 New | 221244-14-0 |
1 NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.
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BCP16358 | TX-1918 New | 503473-32-3 |
TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM).
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BCP22041 | AP-23464 | 845895-51-4 |
AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases, displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells (IC(50) = 14 nM. AP23464 ablates Bcr-Abl tyrosine phosphorylation, blocks cell cycle progression, and promotes apoptosis of Bcr-Abl-expressing cells.
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BCP21601 | AP23848 | 834894-21-2 |
AP23848 is a potent Bcr-Abl inhibitor.
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BCP21589 | AST-487 | 630124-46-8 |
AST 487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM.
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BCP25389 | BGG463 | 890129-26-7 |
BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
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BCP28917 | Radotinib Dihydrochloride | 926037-85-6 |
Radotinib, also known as IY-5511, is an orally available, a second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity.
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BCP29532 | Nilotinib hydrochloride | 923288-95-3 |
Nilotinib, also known as AMN-107, is an orally bioavailable aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor with antineoplastic activit
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BCP29509 | BCR-ABL-IN-2 | 897369-18-5 |
BCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1native and ABL1T315I, respectively.
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BCP11714 | AT9283 | 896466-04-9 |
AT9283 is a multi-targeted inhibitor with IC50s of 1.2 nM, 1.1 nM for JAK2 and JAK3, respectively, and is also potent to Aurora A, Aurora B and Abl(T315I).
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