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Src/Bcr Abl

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Src/Bcr Abl

Chemical Structure Cat. No. Product Name CAS No.
TG 100572 Hydrochloride Chemical Structure
 BCP21364 TG 100572 Hydrochloride 867331-64-4
TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
PD 166285 dihydrochloride Chemical Structure
 BCP22349 PD 166285 dihydrochloride 212391-63-4
PD-166285 is a potent and broadly active protein tyrosine kinase inhibitor.
pp60c-src Fragment 521-533 Chemical Structure
 BCP27682 pp60c-src Fragment 521-533 149299-77-4
pp60 c-src (521-533) (phosphorylated) is a peptide corresponding to the pp60c-src carboxy terminal regulatory domain; phosphorylated at Tyr527. Binds to pp60c-src and pp60v-src at the SH2 domain, suppressing their tyrosine kinase activity and transforming potential.
A-770041 Chemical Structure
 BCP30674 A-770041 869748-10-7
A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.
1 NM-PP1 Chemical Structure
 BCP09491 1 NM-PP1 221244-14-0
1 NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.
TX-1918 Chemical Structure
 BCP16358 TX-1918 503473-32-3
TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM).
AP-23464 Chemical Structure
 BCP22041 AP-23464 845895-51-4
AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases, displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells (IC(50) = 14 nM. AP23464 ablates Bcr-Abl tyrosine phosphorylation, blocks cell cycle progression, and promotes apoptosis of Bcr-Abl-expressing cells.
AP23848 Chemical Structure
 BCP21601 AP23848 834894-21-2
AP23848 is a potent Bcr-Abl inhibitor.
AST-487 Chemical Structure
 BCP21589 AST-487 630124-46-8
AST 487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM.
BGG463 Chemical Structure
 BCP25389 BGG463 890129-26-7
BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
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