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FGFR

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FGFR

Chemical Structure Cat. No. Product Name CAS No.
Tyrosine kinase-IN-1 Chemical Structure
BCP30849 Tyrosine kinase-IN-1 705946-27-6
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.
ODM-203 HCl Chemical Structure
BCP30289 ODM-203 HCl ODM-203hcl
ODM-203 is a potent, selective, dual inhibitor of FGFR and VEGFR tyrosine kinases with approximately equal potency towards recombinant FGFR1, 2, 3 and 4, as well as VEGFR1, 2 and 3 (IC50=5-35 nM).
FGF401 Chemical Structure
BCP25143 FGF401 1708971-55-4
FGF-401 is an inhibitor of FGFR4 extracted from patent WO2015059668A1, compound example 83; has an IC50 of 1.9 nM.
ODM-203 Chemical Structure
BCP30030 ODM-203 1430723-35-5
ODM-203 is an orally available inhibitor of the human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs), with potential antiangiogenic and antineoplastic activities.
E-7090 Chemical Structure
BCP29727 E-7090 1622204-21-0
E7090 is an inhibitor of the fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) pathway, with potential antineoplastic activity.
S49076 HCl Chemical Structure
BCP29576 S49076 HCl 1265966-31-1
S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo.
Dovitinib lactate Chemical Structure
BCP27905 Dovitinib lactate 692737-80-7
Dovitinib(CHIR-258; TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) with an IC50 of 5 nM.
H3B-6527 Chemical Structure
BCP17555 H3B-6527 1702259-66-2
H3B-6527 (H3 Biomedicine) is a highly selective FGFR4 inhibitor with potent antitumour activity in FGF19 amplified cell lines and mice.
NSC-12 Chemical Structure
BCP24324 NSC-12 102586-30-1
NSC-12, also known as NSC 172285, is an extracellular FGF trap with significant implications in cancer therapy.
TG 100801 Hydrochloride Chemical Structure
BCP25254 TG 100801 Hydrochloride 1018069-81-2
TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
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