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Autophagy

Chemical Structure Cat. No. Product Name CAS No.
Vacuolin-1 Chemical Structure
BCP35743 Vacuolin-1 351986-85-1
Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.
Urolithin A Chemical Structure
BCP35737 Urolithin A 1143-70-0
Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis.
YM-155 hydrochloride Chemical Structure
BCP35549 YM-155 hydrochloride 355406-09-6
YM155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM.
Procainamide methacrylamide Chemical Structure
BCP35472 Procainamide methacrylamide 78723-47-4
KN92 Chemical Structure
BCP35203 KN92 176708-42-2
KN-92 is an inactive derivative of KN-93.
Autogramin-1 Chemical Structure
BCP35150 Autogramin-1 2375541-73-2
Autogramin-1 potently inhibits autophagy induced by either starvation (IC50=0.17 μM) or mTORC1 inhibition (Rapamycin; IC50=0.44 μM).
Amiodarone Chemical Structure
BCP35085 Amiodarone 1951-25-3
Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
EN6 Chemical Structure
BCP34911 EN6 1808714-73-9
EN6 is a novel covalent autophagy activator targeting cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase which activates mTORC1 via the Rag guanosine triphosphatases.
LC3-mHTT-IN-AN1 Chemical Structure
BCP33879 LC3-mHTT-IN-AN1 486443-73-6
LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins.
Autophinib Chemical Structure
BCP25844 Autophinib 1644443-47-9
Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34.
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